49ers inactives vs. Vikings: Shorthanded Niners missing 2 All-Pro players on Monday Night Football

San Francisco 49ers wide receiver Deebo Samuel (L) and offensive tackle Trent Williams (R)
San Francisco 49ers wide receiver Deebo Samuel (L) and offensive tackle Trent Williams (R) / Wesley Hitt/GettyImages

ESPN. 2-4. 49ers -6.5. 8:15 p.m. ET. 60. 5-1. 42. Monday, Oct. 23. 49ers-vikings gameday

The 49ers can't be thrilled at missing both Deebo Samuel and Trent Williams for Monday Night Football versus the Vikings. But things could be worse.

For the first time all season, the 5-1 San Francisco 49ers are dealing with a fairly serious rash of injuries that impacted a number of high-profile players.

The bulk of injuries stemmed from the Niners' Week 6 loss at the hands of the Cleveland Browns, and those ramifications are going to be felt for San Francisco's next game, a Monday Night Football clash on the road in Week 7 against the 2-4 Minnesota Vikings.

Head coach Kyle Shanahan already ruled out All-Pro wide receiver Deebo Samuel with a shoulder injury he suffered on the first play in Cleveland. The latest reports state that Samuel will miss two weeks but won't have to land on injured reserve.

Samuel will be unavailable for Week 7, however.

Additionally, All-Pro left tackle Trent Williams (ankle) and All-Pro running back Christian McCaffrey made their way onto the 49ers' injury report this week.

One of them found his way onto Week 7's list of inactive players for the primetime showdown in Minnesota.

49ers inactive list vs. Vikings: Deebo Samuel, Trent Williams will miss Week 7

McCaffrey, despite having a slight tear in his oblique, will play against the Vikings despite the associated risks of aggravating the existing injury.

Likewise, linebacker Dre Greenlaw (hamstring) will play, too, after missing last week with a hamstring issue.

Both Williams and Samuel, though, will be included on the Niners' Week 7 inactives:

  • OT Trent Williams
  • WR Deebo Samuel
  • QB Brandon Allen
  • DT Kalia Davis
  • RB Tyrion Davis-Price
  • LB Jaylen Graham
  • TE Brayden Willis

Related story: 49ers vs. Vikings: MNF game time, betting odds, injury report, TV and streaming info

San Francisco promoted veteran receiver Chris Conley up from the practice squad to help alleviate Samuel's absence, but it's also likely fellow wideout Brandon Aiyuk is a prime beneficiary at the position.

Likewise, the 49ers are expected to start backup tackle Jaylon Moore in Williams' stead.

The Niners and Vikings kick off Monday Night Football at 8:15 p.m. ET from US Bank Stadium.

Read more from Niner Noise