It's not horrible news on the injury front for 49ers stars Deebo Samuel and Christian McCaffrey, but it's not exactly good either.
After all, the Niners nearly pulled off a last-second victory against the NFL's top defense, save for a missed field goal by rookie kicker Jake Moody near the end of regulation. Had he made that, San Francisco would still be undefeated.
Considering all the other things that went wrong for head coach Kyle Shanahan's squad, including the worst game of quarterback Brock Purdy's career, going on the road and nearly pulling off a victory against such a defense isn't the worst of outcomes.
Except the injury front.
The 49ers have been relatively lucky here all season long, but the rainy weather and stout Cleveland defense didn't combine to keep the Niners' recent string of good injury luck going.
Left tackle Trent Williams (ankle), running back Christian McCaffrey (oblique, ribs) and wide receiver Deebo Samuel (shoulder) all suffered injuries during the game, and McCaffrey and Samuel eventually were ruled out.
What do we know now?
X-rays reportedly negative on Deebo Samuel, MRI to determine more
Shanahan pointed out the injuries to both Samuel and McCaffrey during this postgame press conference, but it was Pro Football Talk's Josh Alper who cited a source saying X-rays on Samuel's shoulder were negative.
Alper also reported that an MRI will be scheduled to "evaluate the extent of the injury."
There are fewer details on McCaffrey's injury at the moment, but he was able to re-enter the game after suffering the injury, only to exit again after just one play.
Shanahan will again speak to reporters on Monday, and it's likely then that we'll learn more about the extent of both players' injuries and how long, potentially, either will miss time.
Hopefully, both will be back in time for San Francisco's next game, a Monday Night Football showdown on the road against the Minnesota Vikings.