49ers vs. Browns: Trent Williams, Deebo Samuel both suffer in-game injuries

San Francisco 49ers wide receiver Deebo Samuel (L) and left tackle Trent Williams (R)
San Francisco 49ers wide receiver Deebo Samuel (L) and left tackle Trent Williams (R) / Michael Zagaris/GettyImages

The 49ers could potentially be down two of their best players early in Week 6 against the Browns.

The San Francisco 49ers have been relatively fortunate this season on the injury front, suffering relatively minor injuries and few involving their top players.

In Week 6 on the road against the Cleveland Browns, though, the injury bug is potentially biting the Niners a little harder than normal.

San Francisco suffered two injuries to key players, left tackle Trent Williams and wide receiver Deebo Samuel, before the first quarter had even expired. Williams appeared to have his right ankle rolled over, which required him to gingerly walk off the field.

Samuel, meanwhile, was seen on the sideline entering the blue medical tent. At the time, it wasn't quite clear what his injury was.

49ers rule Trent Williams, Deebo Samuel as questionable to return vs. Browns

Williams was seen on the sideline with his helmet on shortly after having his ankle taped, and he was undergoing individual drills while San Francisco's defense was on the field.

Samuel, though, walked back into the locker room.

The 49ers subsequently ruled both players as questionable to return, also announcing Samuel was dealing with a shoulder issue:

Related story: 49ers inactives vs. Browns: Elijah Mitchell in, Dre Greenlaw out

Jaylon Moore has been filling in for Williams at left tackle, while Samuel's absence opens up the door for receivers like Ray-Ray McCloud and Jauan Jennings to see more snaps.

Updates will be coming soon as they arrive.

UPDATE: Williams has since returned to action, but Samuel is back in the locker room.

Samuel, meanwhile, has been ruled out early in the third quarter, and Christian McCaffrey exited with an oblique injury and is questionable to return.

Read more from Niner Noise