49ers game tonight vs. Vikings: Injury report, betting odds, TV and live streaming

42. 60. 49ers -6.5. 8:15 p.m. ET. 5-1. ESPN. Monday, Oct. 23. 49ers-vikings gameday. 2-4

The 49ers square off against the Vikings on Monday Night Football tonight, and we've got everything you need to know right here.

In some ways, the San Francisco 49ers' Week 6 road loss to the Cleveland Browns can be a good thing.

Now at 5-1, the Niners have to get serious about avoiding a two-game losing streak and treat the loss as a wake-up call.

Plus, as any experienced football fan knows, a team that narrowly loses a game the previous week is always exceptionally dangerous the next.

Perhaps the 2-4 Minnesota Vikings are about to find out when they host quarterback Brock Purdy and Co. on Monday Night Football to wrap up Week 7.

49ers injury report vs. Vikings, Week 7

One of the side effects of San Francisco's loss to Cleveland was accumulating a notable injury list, which included three All-Pros in left tackle Trent Williams, running back Christian McCaffrey and wide receiver Deebo Samuel.

Samuel, who is dealing with a hairline fracture in his injured shoulder, has been ruled out, as the 49ers' Week 7 injury report stated:

WR Deebo Samuel (shoulder): OUT
OT Trent Williams (ankle): Doubtful
RB Christian McCaffrey (oblique): Questionable
LB Dre Greenlaw (hamstring): Questionable

Samuel won't return for at least two weeks, but he also won't land on injured reserve.

McCaffrey, meanwhile, is dealing with a slight tear in his oblique but is aiming to play anyway.

Minnesota, however, already has two of its star players on injured reserve, wide receiver Justin Jefferson and defensive end Marcus Davenport, while starting guard Ezra Cleveland (foot) has been ruled out.

When and where is the 49ers vs. Vikings game being played?

Monday Night Football between the Niners and Vikings kicks off on Monday, Oct. 23 at 8:15 p.m. ET from US Bank Stadium in Minneapolis, Minnesota.

49ers vs. Vikings: Week 7 betting odds, spread, over/under

San Francisco originally opened as a seven-point road favorite, according to the oddsmakers at FanDuel. However, with the Samuel news, it's feasible the oddsmakers moved the spread to 6.5 in favor of the red and gold as a result.

The 49ers' moneyline is -295, while the Vikings' moneyline is +240.

The over/under is 43.0.

Game odds refresh periodically and are subject to change.

49ers vs. Vikings TV channel and broadcast

Monday Night Football is broadcasted nationally by ESPN and also carried on ABC. Joe Buck will do play-by-play commentary alongside Troy Aikman, who'll handle color commentary. Lisa Salters will be on the sidelines.

Fans can also tune into ESPN2 for the Manningcast with brothers Peyton Manning and Eli Manning

49ers vs. Vikings live stream

Fans can live stream the game via a number of different options.

In-market fans can either go to 49ers.com to stream the game or download the official 49ers app, while Vikings fans can download their team's official app, too.

fuboTV offers a free seven-day trial for first-time users, and fans can also go to ESPN.com or download the ESPN app to stream the game.