The 49ers hope to get back in the win column after three straight losses, but a tough matchup on the road against the Jaguars presents a challenge.
The San Francisco 49ers and Jacksonville Jaguars couldn't be on more different trajectories.
The Niners, 5-3 after dropping three games in a row, suddenly look like a team contending for a top-five pick in next year's NFL Draft and not the Super Bowl, while the 6-2 Jacksonville Jaguars have won five in a row and are a legitimate threat to a crowded AFC chock full of playoff hopefuls.
Jags quarterback Trevor Lawrence has played like a Pro Bowler during that span, while San Francisco's signal-caller, Brock Purdy, has looked far more like the final pick of a draft rather than a legitimate starter over the last three weeks.
Would the fact the 49ers are coming off a bye week help matters much for the red and gold?
No. Jacksonville is also coming off its bye, too, and the Niners have to travel across the country.
Perhaps San Francisco gets its edge by healing up, though, and the 49ers' Week 10 injury report does have some hope.
49ers injury report vs. Jaguars Week 10
Two of the Niners' best-known players, wide receiver Deebo Samuel (shoulder) and left tackle Trent Williams (ankle) could return from multi-week absences on Sunday.
Samuel was cleared, but Williams will be a gametime decision, according to head coach Kyle Shanahan, and the All-Pro joins some other notable players on the injury report:
- OG Aaron Banks (toe): OUT
- DE Robert Beal Jr. (hamstring): Questionable
- LB Demetrius Flannigan-Fowles (ankle): Questionable
- DT Javon Hargrave (knee): Questionable
- CB Darrell Luter Jr. (knee): Questionable
- OT Trent Williams (ankle): Questionable
- CB Samuel Womack (knee): Questionable
Veteran lineman Jon Feliciano figures to get the start over Banks, while Jaylon Moore has been starting in place of the injured Williams.
Hargrave, something of a surprise addition, will be missed if he's not available, while the Niners also placed second-year defensive end Drake Jackson (knee) on injured reserve.
49ers vs. Jaguars betting odds, spread, over/under and score prediction
San Francisco opened up as a three-point road favorite against Jacksonville, according to the oddsmakers at FanDuel, and that spreak hasn't changed over the course of the week.
The 49ers' moneyline is -172, while the Jaguars' moneyline is +144.
The over/under for the game is 45.5.
As far as our prediction, let's have the Niners getting back in the win column because of their superior talent on both sides of the ball, and they manage to cover, too, after pulling off a 24-14 victory.
Game odds refresh periodically and are subject to change.
What channel is the 49ers game on vs. Jaguars?
Fox will broadcast Sunday's game between San Francisco and Jacksonville, which kicks off from the Jaguars' home turf at TIAA Bank Field on Nov. 12 at 1 p.m. ET.
A good majority of the nation will be able to watch the game, as Joe Davis and Daryl Johnston will have the call.
Related story: How to listen to 49ers-Jaguars game on the radio
49ers vs. Jaguars live stream
Fans who aren't able to watch the television broadcast on cable can stream the game via a number of different options.
49ers next game and schedule
The Niners come home after their East Coast road trip to face another Florida-based team in Week 11, and then it'll be time to start watching more holiday games for Shanahan and Co.
Here are San Francisco's next four games after Sunday's tilt versus the Jags:
- Week 11 vs. Tampa Bay Buccaneers: Sunday, Nov. 19 at 4:05 p.m. ET
- Week 12 @ Seattle Seahawks: Thursday, Nov. 23 at 8:20 p.m. ET (Thursday Night Football)
- Week 13 @ Philadelphia Eagles: Sunday, Dec. 3 at 4:25 p.m. ET
- Week 14 vs. Seattle Seahawks: Sunday, Dec. 10 at 4:05 p.m. ET