The 49ers are back out on the road in Week 6, and they'll look to stay undefeated by knocking off the Cleveland Browns this Sunday.
The undefeated San Francisco 49ers may want to tread carefully for their Week 6 road matchup against the 2-2 Cleveland Browns.
For starters, the Niners are coming off a 42-10 domination over the Dallas Cowboys on Sunday Night Football, and that old-time rivalry game could potentially lead to a let-down performance against a middle-of-the-pack Cleveland squad.
On top of that, the Browns are coming off a bye week, early in the season as it is, but one that affords extra rest and preparation against a Super Bowl-contending San Francisco group.
However, news that Browns quarterback Deshaun Watson is dealing with a shoulder injury that could keep him out of Sunday's game would greatly aid the 49ers' prospects for staying undefeated six weeks into the regular season.
The Niners are back on the road for Week 6, and we've got you covered for what you need to know
When and where is the 49ers vs. Browns game being played?
The Week 6 showdown between San Francisco and Cleveland will kick off on Sunday, Oct. 15 at 1 p.m. ET from Cleveland Browns Stadium in Cleveland, Ohio.
The last time the 49ers played in Cleveland was back in 2015. The Browns won that game 24-10.
49ers vs. Browns TV channel
Fox will broadcast the game with Kevin Burkhardt on play-by-play duties and Greg Olsen adding color commentary.
49ers vs. Browns live stream
Fans who are unable to tune into the television broadcast may stream the game by subscribing to fuboTV, which offers a free seven-day trial for first-time users.
Bay Area fans can also visit 49ers.com or download the official 49ers app to stream the game on preferred devices, while Cleveland-area fans can download the Browns' official app.
49ers vs. Browns Week 6 betting odds
The Niners opened up as 4.5-point road favorites for this game, according to the oddsmakers at FanDuel.
San Francisco's moneyline is -210, while Cleveland's is +176.
The over/under for the game is currently 38.5.