49ers vs. Cardinals best prop bets for Week 11 Monday Night Football

Brandon Aiyuk #11 of the San Francisco 49ers is tackled by Kylie Fitts #49 and Zaven Collins #25 of the Arizona Cardinals (Photo by Christian Petersen/Getty Images)
Brandon Aiyuk #11 of the San Francisco 49ers is tackled by Kylie Fitts #49 and Zaven Collins #25 of the Arizona Cardinals (Photo by Christian Petersen/Getty Images) /

5-4. Monday, Nov. 21. 4-6. 32. 42. ESPN. 49ers -8. 8:15 p.m. ET

The 49ers are technically the road team against the Cardinals on Monday Night Football, but it’s a neutral-site game with some intriguing prop bets.

Officially, the Arizona Cardinals are the “home” team for the Week 11 Monday Night Football tilt at Estadio Azteca in Mexico City against the “visiting” San Francisco 49ers.

But only officially, considering it’s a neutral site as part of the NFL’s 2022 International Series of games.

According to Vivid Seats (h/t Jennifer Lee Chan of NBC Sports Bay Area), nearly 82 percent of the fans in attendance of this NFC West bout will be supporting the Niners, not Arizona, meaning it’ll essentially be a home crowd for head coach Kyle Shanahan and Co:


This probably helps explain why San Francisco is an eight-point road favorite, according to the oddsmakers over at DraftKings, too.

But let’s take a look at some of the other prop bets worth taking a look at for this primetime showdown on Monday night from south of the border.

49ers vs. Cardinals prop bet No. 1: Bet the over (43.5, -110)

OK, so it’s technically not a prop bet, but the over/under for this game has been set at 43.5.

Taking the over certainly sounds enticing enough, especially considering the 49ers and Cardinals are averaging 22 points and 23 points, respectively, per game.

Beyond that, though, Estadio Azteca sits at 7,200 feet above sea level, which is nearly 2,000 feet higher than the Denver Broncos’ Empower Field at Mile High, meaning both teams’ defenses are likely to be completely gassed by the fourth quarter, setting up what’ll likely be plenty of second-half scoring.

49ers vs. Cardinals prop bet No. 2: Opening drive not ending in field goal (-900)

A couple of things here. First, it’s hard to envision a Niners game taking place without a field goal by kicker Robbie Gould. And there are probably plenty of examples where fans can recall Shanahan settling for a field goal on San Francisco’s first possession.

However, the 49ers are actually towards the bottom of the league in field goals made per game (averaging 1.8, which ranks 22nd), while Arizona is even worse (1.5 per game, 26th).

This prop bet is simple: The opening drive, regardless of the team receiving the possession, ends in something other than a field goal. The payout wouldn’t be great, but it’s undoubtedly a safer betting approach.

49ers vs. Cardinals prop bet No. 3: Christian McCaffrey dual-type TD scorer (+650)

This should come about until it happens, and it’s certainly intriguing.

All-Pro running back Christian McCaffrey perhaps created too lofty of expectations by netting the holy trifecta of touchdowns back in Week 8’s win over the Los Angeles Rams, rushing one in, receiving another and then passing for one, too.

Read More: 49ers vs. Cardinals: How to watch, stream Week 11 game in Mexico City

The oddsmakers aren’t looking at McCaffrey to get another holy trifecta anytime soon, but the possibility of him registering two touchdowns (one receiving and another rushing) is something bettors might want to look at.

With +650 on the table for McCaffrey to have a two-score game, one on the ground and another through the air, it’d be easy for 49ers fans to hope McCaffrey has another monstrous game against Arizona.

The Niners and Cardinals kick off on Monday, Nov. 21 at 8:15 p.m. from Estadio Azteca in Mexico City, Mexico.

Game odds refresh periodically and are subject to change.

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