The 49ers look to get into the win column for the first time this season, and a key NFC West bout against the Seahawks is the best place to do it.
Few would have predicted the Seattle Seahawks would sit alone atop the NFC West after one week of NFL action in 2022.
But with the San Francisco 49ers, Los Angeles Rams and Arizona Cardinals all losing their Week 1 matchups, and with the Hawks pulling off a stunner against now-Denver Broncos quarterback Russell Wilson last Monday night, that’s the context.
Week 1 games can always be weird, though, and the Niners are still viewed as a widely superior team in contrast to a rebuilding Seattle squad.
However, divisional games can always be weird, too, and it isn’t as if San Francisco has had a lot of success against its NFC West rivals from up north the last 10 years. And with some key injuries playing a role for head coach Kyle Shanahan and Co., plus inclement weather heading towards the Bay Area, there could be a few equalizers working against the 49ers’ favor.
49ers injury report vs. Seahawks Week 2
The Niners’ run game took a massive hit in the Week 1 loss to the Chicago Bears with No. 1 running back Elijah Mitchell landing on injured reserve with a knee injury. In response, San Francisco inked veteran tailback Marlon Mack to the practice squad, and now he becomes the de facto most-experienced rusher on the team.
Here are the remaining injuries Shanahan reported ahead of Week 2:
- OL Daniel Brunskill (hamstring): OUT
- TE George Kittle (groin): Questionable
Kittle, who missed Week 1 with the same injury, appears to be a game-time decision, and the 49ers would surely prefer a full array of offensive weapons after struggling on that side of the ball over four quarters in Chicago.
NFL weather for 49ers vs. Seahawks Week 2
With wildfires raging in Northern California, the sight of rain will be a welcomed sight. However, after enduring the deluge at Soldier Field in Week 1, San Francisco probably isn’t too thrilled with the prospects of yet more rain coming down at Levi’s Stadium this Sunday.
Fortunately, the latest forecast doesn’t call for a lot of rain, just 40 percent precipitation chances at kickoff, while winds will be south-south easterly at nine miles per hour.
49ers vs. Seahawks odds, spread, over/under & betting pick Week 2
Despite not looking overly sharp in Week 1, the Niners are nevertheless favored over the Seahawks at home for Week 2, the oddsmakers at WynnBET listing San Francisco as a nine-point favorite.
The Niners’ moneyline is at -400, whereas Seattle’s is +310.
The over/under is 41.5.
Considering Shanahan is likely to coach angry after what happened in Week 1, and San Francisco does boast the vastly superior roster, especially in light of the Seahawks losing safety Jamal Adams to injury for the foreseeable future, let’s go ahead and predict the 49ers walking away with a solid 24-17 Week 2 win to get to the .500 mark.
What channel is the 49ers game on Week 2?
The Niners and Hawks kick off on Sunday, Sept. 18 at 4:05 p.m. ET from Levi’s Stadium in Santa Clara.
Fox will broadcast the game on television, and Adam Amin will do the play-by-play commentary with Mark Schlereth doing color analysis. Kristina Pink will be on the sidelines.
The bulk of Northern California, parts of Wyoming, almost all of Idaho and Montana, and both Oregon and Washington will feature the game on Fox’s affiliates.
49ers vs. Seahawks live stream
For fans unable to tune into the live television broadcast, fuboTV offers a free seven-day trial for first-time users to stream the game on preferred devices.
Additionally, in-market fans can watch live on 49ers.com or by downloading the official team app.
49ers next game and schedule
Even though Wilson is no longer in the NFC West, San Francisco still has the “luxury” of playing him again this season, this time in Week 3 when the Niners travel to take on his new team, the Denver Broncos.
Here are the 49ers’ upcoming four games after squaring off against the Seahawks this Sunday:
- Week 3 @ Broncos: Sunday, Sept. 25 at 8:20 p.m. ET
- Week 4 vs. Rams: Monday, Oct. 3 at 8:15 p.m. ET
- Week 5 @ Panthers: Sunday, Oct. 9 at 4:05 p.m. ET
- Week 6 @ Falcons: Sunday, Oct. 16 at 1 p.m. ET