Best NFL prop bets for 49ers vs. Eagles in Week 13

The San Francisco 49ers and the Philadelphia Eagles will face off in a rematch of last year's NFC championship game on Sunday. The 49ers have been one of the best teams in the NFL, let alone the NFC this season.

However, they will see where they stand against the Eagles, who have the best record in the NFL at 10-1. I found two 49ers props that should be on bettors' radars and an Eagles prop involving their star quarterback.

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Best NFL Prop Bets for 49ers vs. Eagles in Week 13

• George Kittle OVER 45.5 receiving yards (-115)
• Deebo Samuel OVER 49.5 receiving yards (-115)
• Jalen Hurts OVER 10.5 rushing attempts (+105)

George Kittle OVER 45.5 receiving yards (-115)

It wouldn’t be shocking to see Kittle receive a lot of targets on Sunday against an Eagles defense that’s struggled to stop opposing tight ends this season. Philadelphia’s defense is ranked 32nd in DVOA-TE and giving up 48.9 receiving yards per game, per ftnfantasy.com.

Kittle is coming off a quiet performance against the Seahawks last week, where he only had three receptions (five targets) for 19 yards. However, that doesn’t take away from what he’s done over the last five games – 28 receptions (36 targets) for 451 yards and two touchdowns.

The Eagles' defense will also be without starting linebacker Zach Cunningham (hamstring), making this a good spot for Kittle to attack the middle of the field. Kittle has gone OVER 45.5 receiving yards in six out of 11 games. But he’s only averaging 43.8 yards per game on the road.

Deebo Samuel OVER 49.5 receiving yards (-115)

Samuel played well in the 49ers’ double-digit win over the Seahawks on Thanksgiving. He had seven receptions (nine targets) for 79 yards, 15 rushing yards, and a rushing touchdown. It was a complete performance from the versatile receiver, who needs a big game on Sunday for the 49ers to defeat the 10-win Eagles.

Philadelphia’s defense has struggled against the pass this season, allowing 255.7 passing yards per game (fourth-most in the NFL). The Eagles are also ranked 27th in DVOA-WR2 and allowing 48.6 receiving yards per game, per ftnfantasy.com. 

Samuel will be covered by Darius Slay and James Bradberry, who allow some big plays and catches. The 27-year-old receiver has gone OVER 49.5 receiving yards in six out of nine games this season.

Jalen Hurts OVER 10.5 rushing attempts (+105)

The MVP frontrunner has made plays with his legs over the last two games against Kansas City and Buffalo and will need to do it again vs. the 49ers on Sunday. San Francisco doesn’t give up a ton of yards to QBs (125) or attempts (42), but we’ll bank on Hurts getting at least 11 rushing attempts on Sunday.

Since returning from the Week 10 bye, Hurts has had 26 combined rushing attempts vs. the Chiefs and Bills. This season, he’s gone OVER 10.5 rushing attempts in five out of 11 games. However, that was with the caveat of Hurts being injured. It seems like Hurts is healthy, as he’s shown a bit more burst running the ball over the last two games. He will need it, as this 49ers’ defensive line is no joke.

Game odds refresh periodically and are subject to change.