49ers vs. Seahawks: Thanksgiving game time, location, TV and live streaming, odds and more

Niners fans will be very thankful if their team knocks off the Seahawks up in Seattle in front of a national audience this Thanksgiving.

San Francisco 49ers linebacker Fred Warner (L) tackles Seattle Seahawks wide receiver D.K. Metcalf (R)
San Francisco 49ers linebacker Fred Warner (L) tackles Seattle Seahawks wide receiver D.K. Metcalf (R) / Christopher Mast/GettyImages
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6-4. 49ers -7. 8:20 p.m. ET. 7-3. NBC. 49ers Seahawks odds. 42. Thursday, Nov. 23. 36

The 49ers and Seahawks wrap up the trifecta of Thanksgiving Day games with a primetime showdown on Thursday Night Football.

The last time these two NFC West rivals met on Thanksgiving, the San Francisco 49ers and Seattle Seahawks were must-watch television.

True, the rivalry might have taken a step back over the years. But, make no mistake, there's no love lost between these two fanbases. Just ask tight end George Kittle.

The Hawks own a 1-0 lead over the Niners for Thanksgiving games, but head coach Kyle Shanahan and Co. have a chance to return the favor for the Thanksgiving finale on Thursday Night Football in a game that could determine a lot more than just bragging rights and grudges.

With San Francisco holding a one-game lead over Seattle in the NFC West, a victory Thursday night will be vital.

Here's everything you'll want to know about this primetime showdown.

When and where will the 49ers and Seahawks play for Thanksgiving?

The Seahawks are the home team for this Week 12 showdown, and the game will be played at their home venue of Lumen Field in Seattle, Washington.

Kickoff is on Thursday, Nov. 23 at 8:20 p.m. ET.

What TV channel is the 49ers game on vs. Seahawks, Thursday Night Football?

NBC will nationally broadcast Thursday night's game between the Niners and Hawks.

Mike Tirico will handle play-by-play duties, while Cris Collinsworth will do color commentary.

Melissa Stark will be on the sideline.

Related story: How to watch every 49ers game with (and without) cable TV

49ers vs. Seahawks live stream, Week 12

Amazon Prime usually handles Thursday Night Football, but NBC holds the rights to Thanksgiving's game, meaning Amazon Prime will not stream Thursday night's contest this time.

fuboTV offers a free seven-day trial for first-time users wanting to stream the game. Additionally, Peacock subscribers can stream Thursday night's game, as well as fans who go to NBC Sports' website.

49ers vs. Seahawks betting odds, moneyline and over/under, Week 12

The oddsmakers at FanDuel origionally opened up the 49ers as 6.5-point road favorites, but the spread has since increased to -7.

The Niners' moneyline is -335, while the Hawks' moneyline is +270.

The over/under is 43.5.

Game odds refresh periodically and are subject to change.

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