49ers vs. Seahawks prediction, odds, spread, injuries, trends for NFL Thanksgiving

A full betting preview for the San Francisco 49ers' Week 12 matchup against the Seattle Seahawks.
San Francisco 49ers wide receiver Brandon Aiyuk (11)
San Francisco 49ers wide receiver Brandon Aiyuk (11) / Steph Chambers/GettyImages

The San Francisco 49ers will look to keep the good vibes rolling when they play the Seattle Seahawks on Thanksgiving night. The 49ers are now in first place in the NFC West after they defeated the Tampa Bay Buccaneers at home last week.

The Seahawks need to win this game on Thanksgiving as they are a game behind the 49ers for first and cannot afford to lose any more divisional games after last week’s loss to the Rams. It will be tough for Seattle as Geno Smith and Kenneth Walker III are injured.

Below, we’ll break down this pivotal NFC West matchup and give our prediction using odds from DraftKings. 

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49ers vs. Seahawks Odds, Spread and Total

49ers vs. Seahawks Betting Trends

  • San Francisco is 5-5 ATS this season
  • The 49ers are 4-2 ATS in their last six games against Seattle 
  • Seattle is 5-4-1 ATS this season
  • The UNDER is 5-1 in the Seahawks’ last seven games

49ers vs. Seahawks Injury Reports

49ers Injury Report

  • Aaron Banks - G - Questionable
  • Ray-Ray McCloud III - WR - Questionable
  • Shemar Jean-Charles - LB - Questionable
  • Javon Hargrave - DT- Questionable
  • Spencer Buford - OT - Questionable
  • Talanoa Hufanga - S - Out

Seahawks Injury Report

  • Dareke Young - WR - Questionable
  • Jamal Adams - S - Questionable
  • Jerrick Reed II - S - Questionable
  • Jake Bobo - WR - Questionable
  • Riq Woolen - CB - Questionable
  • Tre Brown - CB- Questionable
  • Tyler Lockett - WR - Questionable
  • Coby Bryant - CB - IR
  • Kenneth Walker III - RB - Questionable
  • Geno Smith - QB - Questionable

49ers vs. Seahawks How to Watch

  • Date: Sunday, Nov. 23
  • Game Time: 8:20 p.m. EST
  • Venue: Lumen Field
  • How to Watch (TV): NBC
  • 49ers Record: 7-3
  • Seahawks Record: 6-4

49ers vs. Seahawks Key Players to Watch

San Francisco 49ers

Brandon Aiyuk: Aiyuk has transformed into the 49ers’ No. 1 wide receiver this season, which no one could have seen happening with the team also having Deebo Samuel. The 25-year-old Aiyuk is tied for first in receptions (43) but leads the team in receiving yards (831). The former first-round pick also has four touchdowns. In last week’s game against the Buccaneers, Aiyuk recorded five catches (six targets) for 156 yards and a touchdown. 49ers QB Brock Purdy will be looking for Aiyuk to make some big plays on Thanksgiving night.

Seattle Seahawks

Zach Charbonnet: The rookie running back will likely take over the RB1 duties this week as Walker nurses a strained oblique. Charbonnet was a factor in the running and receiving games last week, recording 69 total yards on 21 touches. The second-round pick hasn’t seen a ton of work this season, with his second-most carries in a game happening in Week 3 against the Panthers (9). However, that will change on Thanksgiving night as Seattle will hope to make some positive gains against a stout 49ers’ run defense.

49ers vs. Seahawks Prediction and Pick

The Niners were sputtering towards the end of last month but have figured out their issues en route to a two-game winning streak. Purdy is playing clean football, which plagued him in San Francisco’s last three games before the bye week.

In his last two games, the second-year quarterback is completing 78.4% of his passes for 629 yards, six touchdowns, and zero interceptions. His improved play has helped the Niners look like the team we saw at the beginning of the season. 

San Francisco has dropped two out of their last three road games but is 2-0 in the NFC West with a road win over the Rams. They are also 2-3 against the spread as a road favorite.

As for the Seahawks, it looks like they will have Smith for Thanksgiving night, but he’s struggled this season, completing 65.3% of his passes for 2,404 yards, 12 TDs, and 7 INTS. Charbonnet should help lessen the pressure on Smith as he’s a viable pass catcher out of the backfield, but this Niners’ front seven is spectacular.

The Seahawks are 4-1 at Lumen Field this season, but their only impressive win was against the Browns in Week 8 (24-20). Therefore, I’ll take the 49ers to cover the spread and win, as they have a slight advantage on both sides of the ball.

Game odds refresh periodically and are subject to change