49ers vs. Rams: Week 2 game time, location, betting odds, how to watch or stream NFC West showdown

At least the 49ers have dominated the Rams during the regular season in recent years, and we're still in the regular season.
San Francisco 49ers linebacker Fred Warner (54) pressures Los Angeles Rams quarterback Matthew Stafford (9)
San Francisco 49ers linebacker Fred Warner (54) pressures Los Angeles Rams quarterback Matthew Stafford (9) / Michael Zagaris/GettyImages

49ers Rams opening. 1-0. 51. 1-0. 42. Sunday, Sept. 17. 49ers -8. 4:05 p.m. ET. Fox

The 49ers square off again with their NFC West rivals, the Rams, in a Week 2 contest down in Southern California this Sunday.

The Arizona Cardinals are largely expected to be the bottom-dwellers in the NFC West this season, but many experts and analysts felt the retooling Los Angeles Rams wouldn't be that far ahead of the red birds in the divisional standings.

After all, those years of general manager Les Snead going all-in for a Super Bowl effectively cost LA its long-term future (although a Super Bowl win was achieved, much to the San Francisco 49ers' chagrin).

Yet Los Angeles pulled off a relatively shocking 30-13 win over another NFC West rival, the Seattle Seahawks, up at Lumen Field in Week 1, which wasn't exactly expected.

So, in tandem with the Niners' 30-7 road victory over the Pittsburgh Steelers, it's now San Francisco and the Rams who are tied atop the NFC West with 1-0 records after one week.

Sure, the division won't be settled in Week 2. But it's time one of these two rivals set itself apart from the other when both teams square off this upcoming weekend.

49ers vs. Rams: Week 2 betting odds, moneyline and over/under

According to the oddsmakers at FanDuel, the 49ers open up as eight-point road favorites over LA for this Week 2 contest, and the Niners currently have a moneyline of -350.

Los Angeles' moneyline is +280, and the over/under for the game is 44.

Game odds refresh periodically and are subject to change.

When, where is the 49ers' game against the Rams in Week 2?

San Francisco's first game against the Rams this season will kick off on Sunday, Sept. 17 at 4:05 p.m. ET from SoFI Stadium in Inglewood, California.

The 49ers are the road team in this contest.

What TV channel is the 49ers game on vs. the Rams?

Fox will broadcast Sunday's contest between the 49ers and Rams.

Kevin Kugler will handle play-by-play duties, while Mark Sanchez will provide color commentary.

How to stream the 49ers' Week 2 game against the Rams

For fans who prefer to stream the Week 2 showdown between LA and the Niners, fuboTV offers a free seven-day trial for first-time users.

In-market fans can go to 49ers.com or download the official 49ers app to stream the game, too.

The Niners lead the all-time series 77-68-3 over their Southern California rivals.

Read more from Niner Noise