49ers vs. Giants: Thursday Night Football game time, location, TV and streaming, betting odds and more

The Niners will look to improve to 3-0 under the bright lights of Thursday Night Football
New York Giants running back Saquon Barkley (26) tries to elude San Francisco 49ers safety Jimmie Ward (20)
New York Giants running back Saquon Barkley (26) tries to elude San Francisco 49ers safety Jimmie Ward (20) / Cary Edmondson-USA TODAY Sports

Amazon Prime. 2-0. 49ers -10. 8:20 p.m. ET. 31. 49ers-Giants opening. 42. 1-1. Thursday, Sept. 21

The 49ers have their 2023 home opener this Thursday night against the visiting New York Giants, and we've got what you'll want to know about the game.

It's always difficult to go 2-0 on a two-game road trip, particularly when one of those games involves traveling clear across the country.

Yet that's what the San Francisco 49ers have done to open up their 2023 campaign, first beating the Pittsburgh Steelers in dominant fashion to open up the regular season, then eventually overcoming the Los Angeles Rams in Week 2.

Now, head coach Kyle Shanahan and Co. return home for the Niners' regular-season home opener, and they'll do so by hosting the 1-1 New York Giants for Week 3's installment of Thursday Night Football.

It'll also be San Francisco's first of five primetime games of the young season.

Where is the 49ers and Giants game going to be played?

The 49ers are the home team for this contest, meaning Week 3 against the G-Men will be played at Levi's Stadium in Santa Clara, California, which is about a 45-minute drive south of San Francisco.

When is the 49ers and Giants game?

The Niners and Giants kick off Thursday Night Football on Thursday, Sept. 21, at 8:20 p.m. ET.

49ers vs. Giants: Betting odds, moneyline and over/under for Week 3

According to the oddsmakers over at DraftKings, San Francisco is a 10-point home favorite over New York, and the 49ers' moneyline is -470.

The Giants' moneyline is +360.

The over/under for the game is currently at 45.

Game odds refresh periodically and are subject to change.

How to watch (or stream) Thursday's game between the 49ers and Giants

Thursday Night Football is carried exclusively by Amazon with the exception of the 2023 regular-season opener between the Detroit Lions and Kansas City Chiefs, which was broadcast nationally by NBC.

Related story: How to watch every 49ers game this season with (and without) cable TV

Fans who want to tune into the Thursday night broadcast will have to have an Amazon Prime account, which will allow them to stream the game onto preferred devices.

In-market fans can also subscribe to NFL+ or visit 49ers.com to stream the game.

The last time the Niners and G-Men played each other was Sept. 27, 2020, and San Francisco won that game 36-9 at MetLife Stadium.

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