49ers game today vs. Cardinals: Week 4 injury report, spread, over/under, schedule, live stream, TV channel

San Francisco 49ers cornerback Deommodore Lenoir (38) vs. Arizona Cardinals wide receiver Marquise Brown (2)
San Francisco 49ers cornerback Deommodore Lenoir (38) vs. Arizona Cardinals wide receiver Marquise Brown (2) / Darren Yamashita-USA TODAY Sports

32. 49ers-Cardinals opening. 3-0. 49ers -14. 42. 4:25 p.m. ET. 1-2. Fox. Sunday, Oct. 1

The 49ers host the Cardinals for a Week 4 NFC West showdown at Levi's Stadium, and Niner Noise has all the details you'll want to know about the game.

The undefeated San Francisco 49ers have a chance to start off the first quarter of the 2023 season with a perfect 4-0 record, and pulling off a victory over the visiting Arizona Cardinals this Sunday will also give head coach Kyle Shanahan's squad two victories within the NFC West.

Those may come in handy down the stretch when looking at the divisional standings and who will take the top spot.

That's a long way away, though, and the Niners are much more focused on ensuring first-year head coach Jonathan Gannon's inaugural trip to Santa Clara, California, in his new role is a sour one.

But Arizona just pulled off a shocking upset over the Dallas Cowboys last week, and Gannon would love nothing more than to get his 1-2 Cardinals back to the .500 mark by beating a division rival, one he helped the Philadelphia Eagles to defeat in the NFC Championship game when he was the defensive coordinator there.

That'll probably be a storyline for Sunday's contest.

Let's break down the latest betting odds, injury report, ways fans can tune into the game live and more!

49ers injury report vs. Cardinals Week 4

After some initial concerns during the week, it appears as if both wide receivers Brandon Aiyuk (shoulder) and Deebo Samuel (ribs, knee) will be available for the contest, the latter being reported as such by ESPN's Adam Schefter early on Sunday morning.

San Francisco is, however, dealing with a few other notable injuries as Schefter pointed out, and here are those named on the team's Week 4 injury report:

  • LB Dre Greenlaw (ankle): Questionable
  • WR Jauan Jennings (shin): Doubtful
  • WR Deebo Samuel (ribs, knee): Questionable
  • LB Demetrius Flannigan-Fowles (ankle): Questionable
  • RB Elijah Mitchell (knee): Questionable

Arizona also ruled out defensive end Jonathan Ledbetter and linebacker Josh Woods for the game.

49ers vs. Cardinals: Week 4 betting odds, lines, spread and over/under

The spread has more or less stayed the same since the game opened, according to the Oddsmakers at FanDuel, who have the 49ers as 14-point home favorites with a moneyline of -1000.

The Cardinals' moneyline is +660, while the over/under is 43.5.

Game odds refresh periodically and are subject to change.

What TV channel is the 49ers and Cardinals game on?

Fox will carry the NFC West showdown between the Niners and Cards, which kicks off on Sunday, Oct. 1 from Levi's Stadium in Santa Clara, California.

Kevin Kugler will do play-by-play with Mark Sanchez on color commentary. Laura Okmin will be on the sidelines.

Most of the West Coast will be able to watch the game on TV, as will almost all of Arizona and parts of Nevada, Idaho and Montana.

Related story: How to watch every 49ers game in 2023 with (or without) cable TV

How to steam 49ers vs. Cardinals Week 4

Fans who want to stream Sunday's game to preferred devices can subscribe to fuboTV, which offers a free seven-day trial for first-time users.

In-market fans can also go to 49ers.com or download the official 49ers app.

49ers upcoming schedule

The Niners stay at home following Sunday's contest against the Cardinals, although Week 5 will be a bit more of a high-profile game and will be played on Sunday Night Football.

Here's San Francisco's next four games after Sunday's tilt:

  • Week 5 vs. Dallas Cowboys: Sunday, Oct. 8 at 8:20 p.m. ET
  • Week 6 @ Cleveland Browns: Sunday, Oct. 15 at 1 p.m. ET
  • Week 7 @ Minnesota Vikings: Monday, Oct. 23 at 8:15 p.m. ET
  • Week 8 vs. Cincinnati Bengals: Sunday, Oct. 29 at 4:25 p.m. ET

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