The 49ers look to sweep the season series against the Cardinals with a Week 15 NFC West showdown out in the desert.
In the meantime, they'd love nothing more than to spoil the San Francisco 49ers' plans to stay in the driver's seat of the NFC.
Currently the No. 1 seed, the 10-3 Niners control their destiny but want to avoid any losses, especially against inferior teams, as other squads like the Philadelphia Eagles and Dallas Cowboys are also hot on the tail for that top spot in the conference.
The last thing quarterback Brock Purdy and Co. want is to fall victim to the ever-present trap game, and Sunday's tilt out in Arizona could be the epitome of one after San Francisco's three consecutive high-profile victories over Philly and the Seattle Seahawks (twice).
Can the 49ers continue their second-half surge by beating the Cardinals, and in doing so, win the NFC West?
That's the plan.
49ers injury report vs. Cardinals
The Niners, unlike much of the year to date, are quite banged up for this contest, and five players are officially listed as OUT on San Francisco's Week 15 injury report:
- DT Arik Armstead (foot, knee)
- DT Javon Hargrave (hamstring)
- LB Oren Burks (knee)
- TE Ross Dwelley (ankle)
- RB Elijah Mitchell (knee)
With Armstead and Hargrave out, backups like Javon Kinlaw should see an increase in field time but will have a tough challenge against an Arizona squad that's averaging 4.7 rush yards per attempt this season, third best in the league.
Additionally, the 49ers have the following players listed as questionable:
- OL Spencer Burford (knee)
- LB Dre Greenlaw (hip, ankle)
- CB Charvarius Ward (groin)
- OL Aaron Banks (questionable)
49ers vs. Cardinals betting odds, spread, moneyline and over/under
The Niners originally opened as 13.5-point road favorites, according to the oddsmakers at FanDuel, but the spread has since narrowed slightly to 12.5 points in favor of San Francisco.
That's still a substantial margin.
The 49ers' moneyline is -770, while the Cardinals' moneyline is +560.
The over/under for the game is 48.
Game odds refresh periodically and are subject to change.
49ers vs. Cardinals TV channel and broadcast
Sunday's game will be one of the rare times that CBS will broadcast a Niners game, which will kick off on Dec. 17 at 4:05 p.m. ET from State Farm Stadium in Glendale, Arizona.
Ian Eagle will do play-by-play duties with Charles Davis doing color commentary.
Related story: 49ers vs. Cardinals Week 15 TV broadcast map
Evan Washburn will be on the sidelines.
49ers vs. Cardinals live stream
Fans who prefer live streaming the game can use fuboTV, which offers a free seven-day trial for first-time users.