49ers can enact vengeance against chief Super Bowl villain in Week 7

The 49ers will face off against their biggest Super Bowl nemesis, Patrick Mahomes and the Chiefs, when the two teams play in Week 7.

At some point, the San Francisco 49ers have to defeat Kansas City Chiefs quarterback Patrick Mahomes.

And it'd be preferable if the Niners were able to do so in the Super Bowl. They've had their crack at him twice now, first in February of 2020 and then again in February of 2024, but head coach Kyle Shanahan's squad ultimately fell short after teasing for much of the game.

Mahomes took home two Super Bowl MVP honors after beating San Francisco twice.

The 49ers haven't had much luck elsewhere against Mahomes either. In two regular-season games against the Niners, Mahomes has remained undefeated while tossing six touchdowns against just one interception.

Needless to say, Mahomes could easily be San Francisco's No. 1 adversary right now, magnified by what's happened in the last two Super Bowl appearances between these two squads.

Hopefully, at least for their sake, the 49ers will have a shot at stumping Mahomes this season.

49ers can exorcise Patrick Mahomes demons when they play Chiefs in Week 7

There's a decent chance KC and the Niners will face each other again in Super Bowl LIX this upcoming February in New Orleans, Louisiana.

But beating Mahomes, finally, would be a solid boost of confidence for Shanahan and the rest of his team.

Turns out, San Francisco hosts Mahomes and the Chiefs on Oct. 25 in Week 7, first reported by NFL insider Jordan Schultz:

Related story: 49ers 2024 regular-season schedule and opponents

Mahomes already has a road win over the 49ers at Levi's Stadium, dating back to the 2022 regular season when Kansas City was in town. But, fresh off a Super Bowl loss, the Niners and their fanbase will be eager to deliver the Chiefs a road loss that could very well go down as a potential Super Bowl preview.

If it's a win for San Francisco, it'll be a small bit of sweet revenge, even if it doesn't come close to relieving the pain from what happened last February.

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