On paper, the 49ers should dominate the Cardinals, but Week 4 is also setting up to be a dangerous trap game for San Francisco.
For whatever the reason, San Francisco 49ers head coach Kyle Shanahan always seemed to have trouble with the Kliff Kingsbury-led Arizona Cardinals. Prior to 2022, Shanahan's Niners had gone 3-7 against their NFC West foes before sweeping the season series last year.
But Kingsbury is gone now, and he's replaced by former Philadelphia Eagles defensive coordinator Jonathan Gannon, who has his team off to somewhat of a surprising 1-2 start when many a pundit felt Arizona might eke out only two or three wins this season.
Beating the Dallas Cowboys 28-16 last Sunday raised some eyebrows.
Meanwhile, San Francisco is coming off a solid Thursday Night Football win over the New York Giants to improve to 3-0 on the season, and the extra bit of rest should do some good with the league hitting the first-quarter point of the year this upcoming weekend.
As expected, the 49ers are heavy favorites in this NFC West showdown, but Gannon and the Cardinals would love nothing more than to embarrass Shanahan and Co. to kick off a new era of this divisional rivalry in total trap-game fashion.
Niner Noise breaks down everything you'll want to know in advance of this matchups.
49ers vs. Cardinals: When and where is the Week 4 game?
San Francisco and Arizona kick off their Week 4 bout on Sunday, Oct. 1 at 4:25 p.m. from the 49ers' home venue, Levi's Stadium, which is located in Santa Clara, California, about 45 minutes south of San Francisco and just outside of San Jose.
49ers vs. Cardinals betting odds
According to the oddsmakers at FanDuel, the Niners opened up as 14-point home favorites with a moneyline of -900, while Arizona's moneyline is +610.
The over/under for the game opened at 43.5.
Game odds refresh periodically and are subject to change.
49ers vs. Cardinals: TV channel and streaming information
Fox will broadcast the game between the Niners and Cardinals. Kevin Kugler will handle play-by-play duties with Mark Sanchez on color commentary.
For those who are unable to tune into the live television broadcast, fuboTV offers a free seven-day trial to stream the game on preferred devices. In-market fans can also go to 49ers.com or download the official 49ers app to stream the game, too.
How to listen to 49ers vs. Cardinals on the radio
As part of the Niners radio network, Bay Area fans can tune into KGO 810 AM or 107.7 The Bone FM to listen to Greg Papa and Tim Ryan. KHTK 1140 will have the broadcast in the greater Sacramento area.
For the Cardinals radio network, KTAR 98.7 FM will cover the greater Phoenix area with other outlier radio stations throughout the rest of Arizona.