The 49ers already beat the Cardinals once this season, but Kyler Murray will be back in action and has historically given the Niners fits.
Two more fowl-related games to play for head coach Kyle Shanahan's squad, and the next will be the second of the yearly two tilts against the NFC West rivals, the 3-10 Arizona Cardinals.
The Niners already beat the red birds 35-16 way back in Week 4, yet Cardinals quarterback Kyler Murray was shelved on injured reserve while recovering from last season's ACL tear, which meant now-Minnesota Vikings quarterback Josh Dobbs got the start.
And actually gave San Francisco some headaches despite the 49ers' victory.
Murray, who owns a 2-3 record against the Niners over his career, could also give some Dobbs-like fits, especially considering the very real possibility of Week 15 being a trap game for Shanahan and Co. after two emotionally charged wins with serious playoff ramifications and after clinching a playoff berth by the end of Week 14.
Niner Noise breaks down what you'll need to know for this NFC West showdown.
When, where will 49ers' Week 15 game vs. Cardinals be played?
San Francisco was the home team in Week 4, meaning the Cardinals will play hosts to the 49ers this go-around at their home venue, State Farm Stadium in Glendale, Arizona.
The game will be on Sunday, Dec. 17 at 4:05 p.m. ET.
While State Farm Stadium is a dome, the weather forecast is calling for cloudy skies and a kickoff temperature of 74 degrees.
49ers vs. Cardinals TV channel
CBS will broadcast the game between the Niners and Cardinals.
The coverage map and announcers will eventually be featured on 506 Sports.
Related story: How to watch every 49ers game with (and without) cable TV
49ers vs. Cardinals live stream
Fans who wish to stream Sunday's NFC West contest can subscribe to fuboTV, which offers a free seven-day trial for first-time users.
In-market fans can go to 49ers.com or download the official 49ers app.
49ers vs. Cardinals betting odds: Spread, moneyline and over/under
Despite being the road team, the Niners are listed as heavy 13.5-point road favorites, according to the oddsmakers over at FanDuel.
San Francisco's moneyline is -1000, whereas Arizona's moneyline is +660.
The over/under for the game is 47.5.
Game odds refresh periodically and are subject to change.