49ers game today: Niners vs. Cardinals injury report, spread, over/under, schedule, live stream, TV channel

General view of the Azteca stadium in Mexico City (Photo credit: JUAN BARRETO/AFP via Getty Images)
General view of the Azteca stadium in Mexico City (Photo credit: JUAN BARRETO/AFP via Getty Images) /

5-4. ESPN. 49ers -8. 8:15 p.m. ET. 42. Monday, Nov. 21. 4-6. 32

The 49ers square off against the Cardinals on Monday Night Football from Mexico City, and we’ve got the latest injury news, odds and how you can watch live.

The San Francisco 49ers are technically the road team for their Week 11 matchup against the Arizona Cardinals on Monday Night Football in Mexico City, Mexico.

But, with an estimated 82 percent of fans attending Estadio Azteca pulling for the Niners, head coach Kyle Shanahan’s squad can pretty much anticipate having the home crowd on its side on Monday night.

Arizona has had its way with San Francisco in recent seasons, going 7-3 against Shanahan since 2017 and winning three of the last four. However, with the 49ers getting healthier and finding some momentum entering the second half of the season, one can understand why they’re eight-point favorites for this contest.

Let’s start off with those injury factors that actually seem to be favoring the Niners for a change.

49ers injury report vs. Cardinals Week 11

For weeks, it seems as if Shanahan’s injury report would be significant and problematic heading into game day. And while San Francisco will still be without defensive tackle Arik Armstead (foot, ankle), it’ll hopefully welcome back its No. 2 pass-rusher, Samson Ebukam, who’s listed as questionable with quad and Achilles injuries.

  • DL Arik Armstead: OUT
  • EDGE Samson Ebukam: Questionable

That’s it from the 49ers’ vantage point.

Meanwhile, Arizona will be without tight end Zach Ertz, who’ll eventually land on season-ending injured reserve because of a knee injury, and cornerback Byron Murphy who is dealing with a back injury.

Additionally, quarterback Kyler Murray (hamstring) is listed as questionable, but the 49ers can’t be too comfortable with that as backup quarterback Colt McCoy helped beat them back in 2021.

49ers vs. Cardinals odds, spread, over/under & betting pick Week 11

The Niners are an eight-point road favorite, according to the oddsmakers over at WynnBET, and they’re likely taking into account the fact Arizona is possibly without Murray and has dealt with second-half struggles under head coach Kliff Kingsbury the last two years.

Plus, the crowd at Estadio Azteca is very San Francisco-centric.

The 49ers’ moneyline is -365, while the Cardinals’ is +290. The over/under for the game is 43.0.

The high altitude at the venue might mean both defenses struggle, particularly in the second half, and Arizona might wind up covering after all.

But the Niners pull away with a 28-21 victory on Monday Night Football regardless.

Game odds refresh periodically and are subject to change.

What TV channel is the 49ers game on Week 11?

Monday Night Football is broadcast nationally by ESPN, which will air the game live from Estadio Azteca in Mexico City, Mexico, on Monday, Nov. 21 at 8:15 p.m. ET.

Read More: YAC Bros. should go off when 49ers play Cardinals in Week 11

Joe Buck will do the play-by-play analysis, while Troy Aikman will provide color commentary. Lisa Salters will be on the sideline.

49ers vs. Cardinals live stream

Fans who are unable to watch the game on television can stream the game by subscribing to fuboTV, which offers a free seven-day trial for first-time users.

Additionally, fans can go to ESPN’s website or download the official ESPN app to stream the game to their preferred devices.

49ers next game and schedule

San Francisco gets to head home after traveling south of the border for Week 11, spending the next three games back at Levi’s Stadium before a fourth game back out on the road.

Here are the 49ers’ next four games:

  • Week 12 vs. New Orleans Saints: Sunday, Nov. 27 at 4:25 p.m. ET
  • Week 13 vs. Miami Dolphins: Sunday, Dec. 4 at 4:05 p.m. ET
  • Week 14 vs. Tampa Bay Buccaneers: Sunday, Dec. 11 at 4:25 p.m. ET
  • Week 15 @ Seattle Seahawks, Thursday, Dec. 15 at 8:15 p.m. ET

Next. Bold predictions for 49ers game vs. Cardinals on Monday night. dark