Predicting 49ers offensive line depth chart (with NFL Draft picks mixed in)

The 49ers can afford to infuse some talent into their offensive line entering 2022, so let’s offer up some predictions how the depth chart takes shape.

It isn’t always a sexy or flashy unit to address, but the offensive line has to be a primary area of focus for the San Francisco 49ers entering 2022.

The Niners already lost two key components from this group during the offseason, especially Pro Bowl left guard Laken Tomlinson, who inked a massive three-year deal in NFL free agency to join the New York Jets. And, while nowhere near as substantial, San Francisco also said goodbye to fill-in starter Tom Compton, who at least decently held the line at right tackle in the wake of Mike McGlinchey’s season-ending quad injury.

On top of all that, the 49ers are facing the reality of center Alex Mack possibly retiring a year from now, assuming he’s fully prepared to return in 2022 despite turning 37 years old this upcoming season.

And with question marks arising at both guard spots, it makes more than enough sense for general manager John Lynch and Co. to invest some NFL Draft capital in long-term replacements and immediate upgrades for the O-line this April.

With likely few other options in free agency and the Niners yet to make their choices in this year’s draft, let’s nevertheless go ahead and take a stab at predicting exactly how San Francisco’s O-line takes shape this upcoming season.

Particularly in light of the 49ers using at least one of their nine selections during the draft on an offensive lineman.

Including one pick, let’s jump out of the gate with the predicted starting offensive line.