5 best quarterbacks 49ers will face on 2022 NFL schedule

Arizona Cardinals quarterback Kyler Murray (1) is pressured by San Francisco 49ers defensive end Arik Armstead (91) Mandatory Credit: Michael Chow-USA TODAY Sports
Arizona Cardinals quarterback Kyler Murray (1) is pressured by San Francisco 49ers defensive end Arik Armstead (91) Mandatory Credit: Michael Chow-USA TODAY Sports /
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San Francisco 49ers, Russell Wilson
Quarterback Russell Wilson (3) Mandatory Credit: Kirby Lee-USA TODAY Sports /

49ers opponent No. 3: Russell Wilson

Sometimes you just can’t move past someone, they keep popping up in your life.

That’s basically what quarterback Russell Wilson is doing with San Francisco.

Wilson, previously the quarterback of the Seahawks, was an absolute thorn in the side of the 49ers since his rookie year in 2012. Seeing the 49ers twice a season, he has a regular-season record of 16-4 against them.

Wilson has also been a top performer in the league upon his arrival, making the Pro Bowl in nine out of his 10 seasons, and winning one Super Bowl along the way. Even in the years in which the Seahawks had a subpar defense, he kept them competitive.

With rumblings of Wilson’s displeasure with the Seahawks starting last season, many felt that 2021 would be his last season with the team.

That was absolutely the case, and he would agree to a trade on March 8, 2022, that sent him to the Broncos for a slew of draft picks and players.

Niners fans might’ve rejoiced a bit knowing that the nine-time Pro Bowler would no longer be in the NFC West, and thus not be playing San Francisco twice a season. But before that could fully sink in, a quick look at the schedule would show that he would still be an opponent in 2022.

So, while the trade signals a rebuild in the Seahawks’ organization, the 49ers will still have one final tough matchup with him in Denver before he goes away for another four seasons.