49ers game Sunday vs. Seahawks: Odds odds and prediction for NFL Week 13 game

The 49ers hope they can help end the Seahawks’ dimming hopes of making the playoffs with a key Week 13 road game at Lumen Field.

Back in Week 4, the Seattle Seahawks helped ensure the San Francisco 49ers would have a losing streak, handing their NFC West rivals their second loss of 2021 en route to what turned into a four-game Niners losing streak early in the season.

Now, heading into Week 13, San Francisco has a chance to return a similar favor, traveling up to Washington with the hopes of smashing what little hopes the Hawks have at getting into the playoffs this season.

The 49ers are fresh off a thrilling and much-needed Week 12 win over the Minnesota Vikings, which saw head coach Kyle Shanahan’s squad improve to 6-5 on the season and move into the No. 6 overall seed in the NFC playoff picture. Meanwhile, the 3-7 Seahawks hope to avoid what’s turned into a two-game skid when they visit the Washington Football Team for the Week 12 finale on Monday Night Football.

And Seattle will also be hoping embattled quarterback Russell Wilson bounces back, too, even though the Niners hope otherwise with the Seahawks currently the No. 15 seed and well out of the playoff picture.

49ers vs. Seahawks odds Week 13

The outcome of the Hawks’ Week 12 matchup isn’t known yet, of course, but the oddsmakers over at WynnBET are already listing San Francisco as a 2.5-point road favorite for this NFC West showdown.

That line could change a lot, both based on how Seattle fares versus the Football Team, as well as the injury news waiting to develop for some of the 49ers’ top contributors, namely linebacker Fred Warner and wide receiver Deebo Samuel, who both exited the game against the Vikings.

It’s possible the line moves either way within the next couple of days.

Currently, though, the Niners’ moneyline for Week 13 is -140, while the Seahawks’ is +120.

The over/under is 46.0.

49ers vs. Seahawks prediction Week 13

Normally, betting on San Francisco’s side for a road game up in Seattle isn’t a good idea. But the Seahawks are falling apart in so many ways, and Wilson hasn’t been able to overcome roster-wide deficiencies over the last two weeks.

Related Story: 49ers watching an end of an era with Russell Wilson, Seahawks

Provided the 49ers get some good injury news with regards to Samuel and Warner, and the turnover problems that nearly cost them the game versus the Vikings don’t repeat, it wouldn’t be a shock to see Shanahan and Co. create even more space between themselves and Seattle in the NFC West.

Especially with the Seahawks having entered Week 12 with the league’s second-worst defense in terms of yards allowed.

It might be tough sledding for the Niners at first, but let’s go ahead and predict San Francisco pushes out to a convincing 28-17 victory in Week 13.

The two teams kick off at Lumen Field in Seattle on Sunday, Dec. 5 at 4:25 p.m. ET.

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