4 biggest challenges 49ers will face in Week 7 bout vs. Colts

No. 3: 49ers’ own rushing attack will be limited

Even though Trent Williams is only officially listed as doubtful, thereby having a 25-percent chance of playing, the sloppy conditions suggest the Niners would be wiser to simply let him heal up to avoid any further injuries.

Nevertheless, Williams’ probable absence isn’t a good thing, especially considering George Kittle is going to be out of the game, which means San Francisco is likely going to be without two of its best run blockers.

So, while the Colts’ own rushing attack is a primary concern, the 49ers may have their challenges in establishing the run, too.

In Williams’ stead, the Niners are likely to field rookie swing tackle Jaylon Moore, who had his share of ups and downs during preseason action and hasn’t played much at all during the regular season.

Meanwhile, Indianapolis is allowing an average of only 4.1 yards per rush, which just so happens to be 10th best in the league entering Week 7, meaning the tandem of running backs Elijah Mitchell and Trey Sermon could be in for a challenging evening.