49ers vs. Seahawks: 5 fantasy football must starts for Week 4

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D.J. Reed, Russell Wilson, San Francisco 49ers, Seattle Seahawks

D.J. Reed Jr. #32 of the San Francisco 49ers pressures Russell Wilson #3 of the Seattle Seahawks (Photo by Michael Zagaris/San Francisco 49ers/Getty Images) /

36. Fox. 2-1. 42. 49ers -3. 1-2. Sunday, Oct. 3. 4:05 p.m. ET

The 49ers’ Week 4 game against the Seahawks presents some juicy offensive opportunities, meaning you’ll want to start these five players.

There’s likely to be plenty of offensive action taking place when the San Francisco 49ers host their NFC West division rivals, the Seattle Seahawks, in Week 4.

Both teams have had plenty of defensive miscues this season to go along with holes on that side of the roster, particularly the Seahawks, who have allowed more yards than any other team this season through three weeks (1,321) and more first downs (84), too.

So, while the Niners offense has been inconsistent at times and has struggled to get things going early the last two weeks, one might figure head coach Kyle Shanahan wants to start off strong in this decisive Week 4 bout.

Fantasy football studs like tight end George Kittle and wide receiver Tyler Lockett are effectively must-start players on a week-to-week basis, so let’s not include them on this list of must starts for your lineups in Week 4. If you have either player, you’re starting him regardless of the matchup.

Instead, here are five other players from this game you’ll want to make sure you get in your fantasy football lineup this weekend.

Fantasy Football Must Start No. 5: Seahawks Quarterback Russell Wilson

Quarterback Russell Wilson is almost guaranteed to be rostered in any league, but there’s a decent chance you have other options available, given only a handful of quarterbacks warrant must-start status on a week-to-week basis.

Don’t overthink this one, though. Get Wilson into your starting lineup against San Francisco.

In 18 regular-season games against the 49ers, Wilson is 14-4 with 32 touchdowns passing (the most against any team) against nine interceptions. And while he’s taken a whopping 47 sacks during that span, the likelihood of him going off in Week 4 against a questionable Niners secondary is awfully high.

As much as it might pain San Francisco fans to start Wilson against the home team, there won’t be any judgment for doing so from the fantasy football perspective.