49ers game Sunday: 49ers vs. Seahawks odds and prediction for NFL Week 4 game

Quarterback Russell Wilson #3 of the Seattle Seahawks (Photo by Ezra Shaw/Getty Images)
Quarterback Russell Wilson #3 of the Seattle Seahawks (Photo by Ezra Shaw/Getty Images) /

The 49ers will look to bounce back from a tough loss in Week 3, this time hosting their NFC West rivals, the Seahawks, in Week 4.

Sometimes, the team that suffers a narrow loss the previous week has a bit of an edge the following week.

At least that’s what the San Francisco 49ers are hoping after they watched quarterback Aaron Rodgers and the Green Bay Packers engineer a last-second drive that culminated in a game-winning field goal on Sunday Night Football in Week 3, handing the Niners their first loss of 2021 by a score of 30-28.

If San Francisco wants to have that edge and get a 3-1 record by the first-quarter mark of the season, it’ll have to deliver the Seattle Seahawks their third loss of the year this upcoming Sunday.

Seattle, coming off back-to-back losses and boasting the NFL’s worst defense, at least in terms of yards allowed, still presents a tough challenge to head coach Kyle Shanahan’s squad.

Niner Noise breaks down the early odds and prediction for this Week 4 bout.

49ers vs. Seahawks odds Week 4

2018 marked the last time the Niners beat Seattle within the comforts of Levi’s Stadium. And despite the Seahawks’ early season struggles this year, the oddsmakers over at WynnBET are still viewing this as an awfully close game, listing San Francisco as a mere 2.5-point favorite for Week 4.

The 49ers’ moneyline is still -150, while the over/under for the contest is set at 52.0.

Taking the Niners’ 17-11 Week 2 win over the Philadelphia Eagles, it might seem smarter to take the over.

49ers vs. Seahawks prediction Week 4

Seahawks quarterback Russell Wilson has never lost three games in a row despite facing that challenge 10 times over the course of his career. As Rodgers seemingly did with ease over the course of Week 3’s game, Wilson will look to make good use of his elite-level duo of wide receivers, D.K. Metcalf and Tyler Lockett, against a very questionable San Francisco cornerback crop this Sunday.

And the Niners still had offensive troubles against a suspect Packers defense, too, suggesting whatever edge Shanahan and Co. might have after suffering a tough defeat last weekend might not be enough to overcome Seattle.

Let’s hope we’re wrong with this one. But it’s too tough a prediction to suggest Seattle loses three games in a row, especially with the Seahawks’ strengths being perfectly aligned to exploit San Francisco’s defensive weaknesses.

Unfortunately, it’s lining up to be something like a 28-21 victory for Seattle, giving the 49ers their own two-game losing streak.

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