SF 49ers: Week 4 game weather, betting odds and injury report vs. Eagles

General view of the San Francisco 49ers. Mandatory Credit: Stan Szeto-USA TODAY Sports
General view of the San Francisco 49ers. Mandatory Credit: Stan Szeto-USA TODAY Sports /

The SF 49ers host the winless Eagles on Sunday Night Football, and Niner Noise breaks down the game-time weather, odds and the latest injury news.

The SF 49ers and Philadelphia Eagles have a lot of things in common as they prepare for their prime-time Week 4 matchup at Levi’s Stadium on Sunday Night Football.

Both teams are currently dealing with a serious rash of injuries, the Niners already losing defensive ends Nick Bosa and Solomon Thomas to season-ending ACL tears. Both squads are hurting at wide receiver, San Francisco missing second-year pro Deebo Samuel to a foot injury the first three weeks, while Philly is expected to be without wideouts Alshon Jeffery and DeSean Jackson for the game.

On top of that, both squads made the Super Bowl not long after being head coached by Chip Kelly, as Eric Ting of SFGate.com pointed out in this article comparing the two teams.

Yet the SF 49ers have managed to get out to a 2-1 record to open up the season, pulling off back-to-back wins over the New York Jets and New York Giants at MetLife Stadium in Weeks 2 and 3. The Eagles, meanwhile, enter this bout with an 0-2-1 record after tying the Cincinnati Bengals last week.

Additionally, Eagles head coach Doug Pederson’s offense ranks 28th in scoring and is dead last with an average of 4.6 pass yards per attempt through three weeks.

This alone influences why the Niners are looked at as home favorites for this contest.

Eagles vs. SF 49ers: Betting odds and lines

The Action Network currently has San Francisco as minus-7 favorites for this Sunday night matchup.

The over/under is 46.

The money line is currently heading towards the 49ers, with The Action Network tabbing minus-303 for San Francisco. Philly’s best bet is plus-265.

Sunday Night Football game weather

It’s been typically warm in Northern California for late September and early in October, and the heat is expected to continue into the early evening of Sunday night.

The current kickoff forecast is 74 degrees with west-by-northwest winds of six miles per hour. Skies will be clear, and the humidity will be at 55 percent.

Eagles vs. SF 49ers: Each team overcoming significant injuries

Depth has proven to be a bonus for San Francisco, as the 2-1 record despite injuries suggests. Philadelphia, meanwhile, has some serious depth concerns.

Still, injuries are never good regardless which team is going through them.

SF 49ers

  • EDGE Dee Ford (back): OUT
  • QB Jimmy Garoppolo (ankle): OUT
  • LB Dre Greenlaw (quad): OUT
  • CB Emmanuel Moseley (concussion): OUT
  • RB Raheem Mostert (knee): OUT
  • TE Jordan Reed (knee): OUT
  • CB K’Waun Williams (hip): Questionable
  • CB Ahkello Witherspoon (hamstring): OUT

Garoppolo was given Friday to see whether or not he’d be ready to fully suit up for Sunday’s action, yet it’s looking as if No. 2 quarterback Nick Mullens will make his second start of the year on Sunday night after passing for 343 yards and a touchdown in the win over the Jets.

While San Francisco’s injury woes are serious, there’s good news with tight end George Kittle returning in full from a two-week injury absence because of a knee injury suffered in Week 1. Likewise, wide receiver Deebo Samuel will make his season debut after missing the first three weeks of the season after recovering from offseason foot surgery.

That’ll surely help Mullens.


  • WR J.J. Arcega-Whiteside (calf): Doubtful
  • WR DeSean Jackson (hamstring): OUT
  • WR Alshon Jeffery (foot): OUT
  • CB Avonte Maddox (ankle): OUT
  • T Jason Peters (foot): Questionable
  • CB Trevor Williams (ribs): OUT

If fans are thinking the Niners are banged up, the Eagles’ injury-report list is truly awful.

Especially at wide receiver, where Philly is expected to be without Jackson and Jeffery, two of quarterback Carson Wentz’s two most-prolific targets. Additionally, wide receivers Jalen Reagor and Quez Watkins are on injured reserve, along with No. 2 tight end Dallas Goedert.

This will put much more pressure on Wentz to involve what’s his obvious No. 1 option in the passing game, tight end Zach Ertz, who’ll now be the primary focus for San Francisco’s defense.

Next. Eagles vs. 49ers: 5 matchups that'll determine Week 4 outcome. dark

The SF 49ers and Eagles kick off on Sunday Night Football on Oct. 4 at 8:20 p.m. ET from Levi’s Stadium in Santa Clara.