No. 2: 49ers Run Defense vs. Kenyan Drake
The Niners don’t have many defensive weaknesses this season. But if there is one area of concern so far in 2019, it’s been against the run.
Through nine games, the 49ers are allowing an average of 4.6 yards per carry to opponents — good for 24th — and more than a handful of teams have used this to their advantage over the course of the season.
The situation won’t be made any easier, thanks to the season-ending pectoral injury suffered by linebacker Kwon Alexander. True, rookie linebacker Dre Greenlaw stepped in nicely during the loss to Seattle last week. But San Francisco will be facing yet another tough ground challenge Arizona will likely feature.
Running back Kenyan Drake.
Drake was a monster back in Week 9, rushing for a whopping 110 yards on 15 carries with a touchdown, also adding 52 more yards on four catches through the air.
Perhaps the 49ers focus on shutting Drake down in this contest by stacking the box, too. Yet that opens up another problem San Francisco will have to deal with as a result, Cardinals quarterback Kyler Murray.