No. 3: Deebo Samuel vs. Cardinals Secondary
Despite having some issues with the drops in Week 10 against the Seahawks, wide receiver Deebo Samuel was still San Francisco’s top receiving option, finishing the contest with an impressive 112 receiving yards on eight receptions.
Like the situation with Tevin Coleman and the running game, Samuel’s potential production against the Cardinals is largely contingent on injuries and availability.
Tight end George Kittle (ankle/knee) is doubtful for the game, while No. 1 wide receiver Emmanuel Sanders is questionable with a ribs injury. Even if Sanders is made available for Sunday’s game, however, Samuel could wind up being the player to watch.
Sanders made the Cardinals’ No. 1 cornerback, Patrick Peterson, look bad back in Week 9. Yet there’s no reason to assume Peterson won’t shadow Sanders again, should the latter suit up.
That opens the door for Samuel to be the shoo-in No. 2 option, in that case, and he could see plenty of one-on-one matchups if Arizona elects to stack the box against San Francisco’s ground attack.
If Samuel is on point and contributing like he did last week, the Cardinals’ 24th-ranked pass defense will be in for a long day.