Cardinals vs. 49ers: 5 matchups to watch in Week 11 for San Francisco

The San Francisco 49ers will look to put their tough Week 10 loss to the Seattle Seahawks behind them, as they host the still-feisty Arizona Cardinals at Levi’s Stadium in Week 11. Here are five matchups to watch in the game.

Undefeated no longer, the 8-1 San Francisco 49ers will look to avoid their first losing streak of 2019 in Week 11, as they prepare to host another NFC West division rival, the 3-6-1 Arizona Cardinals, on Sunday at Levi’s Stadium.

In some ways, the Niners’ 27-24 overtime loss to the Seattle Seahawks on Monday Night Football was a good thing. Cornerback Richard Sherman told reporters after the game “you learn more from a loss than a win,” and San Francisco can take away a number of key lessons it can now implement over the final stretch of the regular season.

And while the Cardinals aren’t eyeing the playoffs this year, they more than proved they could be a tough challenge for the 49ers, as head coach Kyle Shanahan’s squad staved off a second-half comeback by Arizona the last time these two teams met — a 28-25 narrow Niners win back on Thursday Night Football in Week 9.

In a game when the Cardinals mostly shut down San Francisco’s rushing attack, quarterback Jimmy Garoppolo responded with a career-high four-touchdown game.

It might take that kind of effort again, if Cardinals head coach Kliff Kingsbury and Co. elect to do the same by stacking the box against Shanahan’s run-first style.

But this won’t be easy, as the 49ers are dealing with some notable injuries at the skill positions on offense.

Currently, the Niners are listed as 10.5 home favorites against Arizona, according to the Action Network.

For those odds to come true, however, San Francisco will need to win the majority of these five key matchups on Sunday.