49ers win vs. Giants in Niner Noise's straight-up picks for Week 10

According to Niner Noise’s complex, sophisticated prediction machine, the San Francisco 49ers will beat the New York Giants in Week 10, and here are the rest of the picks.

It’s weird to think the San Francisco 49ers get to play in back-to-back prime-time games, especially when those opponents, the Oakland Raiders and New York Giants, have a combined record of 2-14.

And at 2-7, the Niners aren’t exactly flying high either. But they have to feel pretty good after upstart quarterback Nick Mullens carved up Oakland’s defense with ease on Thursday Night Football in Week 9.

Now, San Francisco hosts embattled quarterback Eli Manning and the one-win Giants on Monday Night Football to close out Week 10. The Niners currently sit as three-point favorites for the game, according to Odds Shark. And while the Giants might be a bit better than the Raiders, defensively, Manning and the G-Men’s offense has been abysmal.

There should be three key X-factors for this game: a budding 49ers pass rush versus a suspect New York offensive line, stopping rookie running back Saquon Barkley and Mullens’ budding maturation.

No team in the NFL has given up more sacks than the Giants this year (31). So it shouldn’t come as a surprise Football Outsiders ranks New York’s O-line dead last in pass protection entering Week 10.

This bodes well for a 49ers team that racked up eight sacks versus the Raiders last week and is now up to 24 on the year.

If Mullens performs close to the level seen last week, the pass rush gets home against Manning and Barkley is contained to the best of the defense’s abilities, the 49ers should have no trouble pulling off their first winning streak of 2018.

Prediction: 49ers 28, Giants 17

Let’s dive into the remaining slate of Week 10 games and offer up our NFL predictions for each, shall we?

Redskins @ Buccaneers

Washington is coming off an embarrassing 38-14 home loss to the Falcons last week, and the Redskins should be pissed about that. They’ll take their anger out on a Buccaneers team allowing more points against than any other through Week 9 (275).

Prediction: Redskins 31, Buccaneers 24

Bills @ Jets

The Jets are bad, and rookie quarterback Sam Darnold is going through his growing pains. But the Bills are far worse. So is their own QB situation.

Prediction: Jets 17, Bills 9

Cardinals @ Chiefs

Really?

Prediction: Chiefs 38, Cardinals 13

Jaguars @ Colts

Jacksonville has been a head scratcher this season, while the Colts look to be getting back on the right foot after years of mismanagement. But the Jaguars are coming off a bye week, meaning they should be both fresh and adequately prepared for this road bout against a suspect Indy defense.

INDIANAPOLIS, IN – OCTOBER 22: Blake Bortles #5 of the Jacksonville Jaguars scrambles against the Indianapolis Colts during the third quarter at Lucas Oil Stadium on October 22, 2017 in Indianapolis, Indiana. (Photo by Andy Lyons/Getty Images) /

The Jags end the four-game losing streak.

Prediction: Jaguars 23, Colts 17

Patriots @ Titans

At this point, it’s anyone’s guess why people still bet against the Patriots.

Prediction: Patriots 27, Titans 14

Falcons @ Browns

Atlanta managed to sign EDGE Bruce Irvin, and he’ll help reinforce what has turned to an injury-plagued, bad Falcons defense a bit. After being drubbed by another high-flying offense, the Chiefs, in Week 9, it’s not likely the Browns will able to rebound against a Falcons team averaging 31.7 points the last three weeks.

Prediction: Falcons 34, Browns 13

Saints @ Bengals

Everyone knows quarterback Drew Brees’ favorite target is wide receiver Michael Thomas.

Thomas should put on a show against the Bengals Sunday after a 200-plus yard performance versus the Rams last week.

Prediction: Saints 33, Bengals 24

Lions @ Bears

Guess what? That Bears defense is pretty darned good again, isn’t it.

Prediction: Bears 27, Lions 17

Chargers @ Raiders

At this point, Oakland head coach Jon Gruden should sit all his starters and see if he has anybody in the backup roles who might be worth keeping around after this season.

Prediction: Chargers 28, Raiders 13

Dolphins @ Packers

Which quarterback would you rather have? The Dolphins’ Brock Osweiler in place of Ryan Tannehill (shoulder) or the Packers’ Aaron Rodgers?

Yeah, thought so.

Prediction: Packers 27, Dolphins 14

Seahawks @ Rams

This might be a fun game. But let’s face it, the Rams will be pretty upset about their tough road loss to the Saints last week. And that was a game in which L.A.’s offense was still performing at an awfully high level.

The Seahawks haven’t been as terrible this season as anticipated, defensively. And quarterback Russell Wilson has done his share to carry the offense.

Still, let’s give it to what still is the NFL’s best team through nine weeks.

Prediction: Rams 28, Seahawks 18

Cowboys @ Eagles

NFC East matchups are always fun to watch. And we’ll have to see if former Raiders wide receiver Amari Cooper can continue to provide a boost for Cowboys quarterback Dak Prescott.

The Eagles haven’t exactly been their Super Bowl-winning selves this season. But they’re also fresh off a bye week hosting a Dallas squad coming off a short week after losing to the Titans on Monday Night Football.

That, and it’s a home game for Philly.

Next. Ranking the top 10 49ers halfway through 2018. dark

Prediction: Eagles 24, Cowboys 17

49ers win vs. Giants in Niner Noise’s straight-up picks for Week 10

By Peter Panacy | Nov 9, 2018