Titans vs. 49ers: Full Week 15 preview for San Francisco

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SANTA CLARA, CA – NOVEMBER 12: Jason Pierre-Paul #90 of the New York Giants rushes against Trent Brown #77 of the San Francisco 49ers during their NFL game at Levi’s Stadium on November 12, 2017 in Santa Clara, California. (Photo by Ezra Shaw/Getty Images) /

Significant injuries

As mentioned previously, the 49ers are going to be missing offensive Trent Brown due to a shoulder injury. Head coach Kyle Shanahan announced on Friday that the team was placing Brown on injured reserve, ending the third-year player’s season.

The move makes sense, considering San Francisco’s record and the value of Brown. Shanahan noted this in his decision-making (h/t Matt Barrows of the Sacramento Bee):

"Trent’s a very important part of this place in our future, Shanahan said. When you’re talking about a five or six month injury, that’s something we want to get going as fast as possible, and I fully support his decision."

As for the rest of the 49ers, this is how the injury report is looking for the game against the Titans, via ESPN’s Nick Wagoner:

Questionable — CB Ahkello Witherspoon (knee), CB Greg Mabin (calf).