49ers vs. Bears: Full Week 13 preview for San Francisco

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SANTA CLARA, CA – NOVEMBER 12: Jason Pierre-Paul #90 of the New York Giants rushes against Trent Brown #77 of the San Francisco 49ers during their NFL game at Levi’s Stadium on November 12, 2017 in Santa Clara, California. (Photo by Ezra Shaw/Getty Images) /

Significant injuries

All season long, it has been an uphill battle fighting injuries. Since the season began, the 49ers have placed 19 players on injured reserve. Most recent were running back Raheem Mostert and offensive lineman Erik Magnuson.

Good news for San Francisco is that offensive lineman Trent Brown is on his way to returning from a shoulder injury that sidelined him last game. Adrian Colbert continues to make progress as well.

Here is the full report, courtesy of ESPN’s Nick Wagoner:

"49ers Friday injury report: Questionable — OT Trent Brown (shoulder), S Adrian Colbert (thumb), CB Ahkello Witherspoon (ankle)."