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San Francisco 49ers: Full Win/Loss Predictions for All 16 Games

By Bobby Horne

January 20, 2016; Santa Clara, CA, USA; Chip Kelly poses for a photo after being introduced as the new head coach for the San Francisco 49ers at Levi's Stadium Auditorium. Mandatory Credit: Kyle Terada-USA TODAY Sports
January 20, 2016; Santa Clara, CA, USA; Chip Kelly poses for a photo after being introduced as the new head coach for the San Francisco 49ers at Levi's Stadium Auditorium. Mandatory Credit: Kyle Terada-USA TODAY Sports /
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Dec 27, 2015; Orchard Park, NY, USA; Buffalo Bills quarterback Tyrod Taylor (5) looks to pass during the second half against the Dallas Cowboys at Ralph Wilson Stadium. Buffalo defeat Dallas 16-6. Mandatory Credit: Timothy T. Ludwig-USA TODAY Sports
Dec 27, 2015; Orchard Park, NY, USA; Buffalo Bills quarterback Tyrod Taylor (5) looks to pass during the second half against the Dallas Cowboys at Ralph Wilson Stadium. Buffalo defeat Dallas 16-6. Mandatory Credit: Timothy T. Ludwig-USA TODAY Sports /

Week 6

Where: Sunday, October 16th

Who: Buffalo Bills

Where: Ralph Wilson Stadium

The 49ers travel east to face a Bills team that’s on the verge of becoming playoff bound. It has the makings of what will prove to be a hard-fought football game but, in the end, the Bills are just a better team at this point.

Key Matchup: Carlos Hyde vs. Reggie Ragland

Hyde should see a lot of touches in Buffalo, which also gives him more shots at the best run-stopping linebacker from the 2016 draft in Ragland. A very intriguing matchup to watch.

Prediction: Loss

Next: Week 7