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San Francisco 49ers: Full Win/Loss Predictions for All 16 Games

By Bobby Horne

January 20, 2016; Santa Clara, CA, USA; Chip Kelly poses for a photo after being introduced as the new head coach for the San Francisco 49ers at Levi's Stadium Auditorium. Mandatory Credit: Kyle Terada-USA TODAY Sports
January 20, 2016; Santa Clara, CA, USA; Chip Kelly poses for a photo after being introduced as the new head coach for the San Francisco 49ers at Levi's Stadium Auditorium. Mandatory Credit: Kyle Terada-USA TODAY Sports /
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Sep 27, 2015; Glendale, AZ, USA; Arizona Cardinals running back David Johnson (31) breaks a tackle by San Francisco 49ers outside linebacker Eli Harold (58) and inside linebacker NaVorro Bowman (53) during the second half at University of Phoenix Stadium. Mandatory Credit: Matt Kartozian-USA TODAY Sports
Sep 27, 2015; Glendale, AZ, USA; Arizona Cardinals running back David Johnson (31) breaks a tackle by San Francisco 49ers outside linebacker Eli Harold (58) and inside linebacker NaVorro Bowman (53) during the second half at University of Phoenix Stadium. Mandatory Credit: Matt Kartozian-USA TODAY Sports /

Week 5

When: Thursday, October 6th

Who: Arizona Cardinals

Where: Levi’s Stadium

The second and final prime-time game of the season comes against a very good Cardinals team. Once again, the 49ers are faced with an extremely tough matchup against a Super Bowl-ready team. This will not be a fun night for the 49ers.

Key Matchup: Colin Kaepernick vs. Cardinals Secondary

After throwing 4 interceptions the last time Kaepernick played against the Cardinals, he will look for some revenge. He won’t find any on this night, but it will still be a matchup to watch.

Prediction: Loss

Next: Week 6