Packers vs. 49ers prediction, odds, spread, injuries, trends for NFL divisional round

Dec 17, 2023; Glendale, Arizona, USA; San Francisco 49ers quarterback Brock Purdy (13) against the
Dec 17, 2023; Glendale, Arizona, USA; San Francisco 49ers quarterback Brock Purdy (13) against the / Mark J. Rebilas-USA TODAY Sports

The San Francisco 49ers enjoyed a week of rest but now it's time to get back to work. As the No. 1 seed, they'll welcome the No. 7 seed, the Green Bay Packers, in the Divisional Round of the NFL Playoffs.

The 49ers, who are viewed as the best team in the NFL by many people, are unsurprisingly set as sizable favorites to the Packers. In this article, I'm going to break down everything you need to know to bet on this game.

If you want to get in on the action this weekend, be sure to sign up for an account at FanDuel Sportsbook. If you click the link below to sign up for an account, you'll receive $150 in bonus bets when you place your first $5 wager.

Bet on the 49ers at FanDuel now!

Packers vs. 49ers odds, spread, and total

Packers vs. 49ers betting trends

  • Packers are 6-3 ATS in their last nine games
  • The OVER is 7-1 in the Packers' last eight games
  • The OVER is 6-0 in the Packers' road games
  • Packers are 8-1 ATS in their last nine games vs. NFC West opponents
  • 49ers are 0-5 ATS in their last five home games
  • 49ers are 13-3 ATS in their last 16 games played in January

Packers vs. 49ers injury reports

Green Bay Packers injury report

  • Preston Smith - LB - Questionable
  • Isaiah McDuffie - LB - Questionable
  • AJ Dillon - RB - Questionable
  • Christian Watson - WR - Questionable
  • Jayden Reed - WR - Questionable

San Francisco injury report

  • Logan Ryan - S - Questionable
  • Arik Armstead - DE - Questionable
  • Dre Greenlaw - LB - Questionable

Packers vs. 49ers how to watch

  • Date: Saturday, January 20
  • Game Time: 8:15 pm ET
  • Venue: Levi's Stadium
  • How to Watch (TV): FOX
  • Green Bay Packers Record: 9-8
  • San Francisco 49ers Record: 12-5

Packers vs. 49ers key players to watch

Green Bay Packers

Aaron Jones: Everyone is talking about Jordan Love recently, for good reason, but Aaron Jones has quietly strung together great performances of late. He has ran for 110+ yards in four straight games including 118 yards and three touchdowns against the Cowboys last week. If they can get Jones going this week, they're going to have a chance to pull off the upset.

San Francisco 49ers

Brandon Aiyuk: The 49ers No. 1 receiver doesn't get enough credit for his performance this season. He hauled in 75 receptions for 1,342 yards and seven touchdowns in 16 games. He can attack this weak Packers secondary and could be their key to covering this big spread.

Packers vs. 49ers prediction and pick

By the majority of metrics you want to look at, the San Francisco 49ers are the best team in the NFL. Sure, you could argue that title belongs to the Ravens due to them beating the 49ers late in the season, but the metrics generally rank the 49ers higher.

For example, the enter the playoffs ranking first in Net Yards per Play (+1.6), EPA per play, and Success Rate. Their offense is dynamic and effective and few teams have had an answer for them all season and I don't think the Packers will either.

The Packers offense became a top 10 unit, bordering on top five by the end of the season, but a team that challenges the 49ers has to be a team that can play defense and the Packers absolutely can not do that.

The Packers are 20th in opponent yards per play (5.4), 23rd in opponent EPA per play, and 26th in opponent success rate. The 49ers offense is going to have their way with them.

Green Bay's offense may need to score on every possession in order to keep pace with San Francisco and I just don't see the Packers being able to do that. I'll lay the points with the 49ers.

Odds refresh periodically and are subject to change.

You can check out all of Iain's bets here!