Lions vs. 49ers prediction, odds, spread, injuries, trends for NFC Championship Game

Get ready for the NFC Championship showdown between the San Francisco 49ers and the Detroit Lions. Find out everything you need to know to wager on this exciting game!

San Francisco 49ers running back Christian McCaffrey (23) quarterback Brock Purdy (13) and wide receiver Deebo Samuel (19)
San Francisco 49ers running back Christian McCaffrey (23) quarterback Brock Purdy (13) and wide receiver Deebo Samuel (19) / Robin Alam/ISI Photos/GettyImages

The San Francisco 49ers survived a scare against the Green Bay Packers and now advance to the NFC Championship to take on the Detroit Lions.

For the majority of the season, the 49ers have been undoubtedly the best team in the NFC, but now is their chance to prove it. A win will send them back to the Super Bowl for the first time since 2019 and it will set them up for a rematch with one of the two teams they lost to in their latest two appearances, the Baltimore Ravens or Kansas City Chiefs.

But before they get there, they need to take care of business against the Detroit Lions. In this article, I'm going to break down everything you need to know to wager on this Sunday's NFC Championship.

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Lions vs. 49ers odds, spread, and total

Lions vs. 49ers betting trends

  • Lions are 5-1 ATS in their last six games
  • The OVER is 8-3 in the Lions' last 11 games
  • Lions are 1-11 straight up in their last 12 games vs. 49ers
  • Lions are 8-2 ATS in their last 10 road games
  • Lions have lost 10 straight games in San Francisco
  • 49ers are 0-6 ATS in their last six home games
  • 49ers are 13-4 ATS in their last 17 games played in January

Lions vs. 49ers injury reports

Detroit Lions injury report

  • Jonah Jackson - G - Questionable
  • Frank Ragnow - C - Questionable
  • Kalif Raymond - WR - Questionable
  • Brock Wright - TE - Doubtful
  • James Houston - LB - Questionable

San Francisco 49ers injury report

  • Deebo Samuel - WR - Questionable
  • Clelin Ferrell - DE - IR

Lions vs. 49ers how to watch

  • Date: Sunday, January 28
  • Game Time: 6:30 p.m. EST
  • Venue: Levi's Stadium
  • How to Watch (TV): FOX
  • Detroit Lions Record: 12-5
  • San Francisco 49ers Record: 12-5

Lions vs. 49ers key players to watch

Detroit Lions

Amon-Ra St. Brown: The Lions No. 1 receiver has been even better in the postseason than he was in the regular season and has been a huge part in Detroit's first two wins. He already has 15 receptions for 187 yards and a touchdown in two games and whenever they need a big play, he comes up big. He's going to be keep in keeping the Lions' momentum going this weekend.

San Francisco 49ers

Brandon Aiyuk: With Deebo Samuel questionable for the game, Brandon Aiyuk needs to step up in a big way in the passing game. He has the matchup to do it as the Lions have allowed opposing receivers to put up big numbers against them these playoffs. Look for Aiyuk to have a productive outing.

Lions vs. 49ers prediction and pick

I still believe the 49ers are the best team in the NFL and a lot of metrics would back that up. They lead the league in Net Yards per Play at +1.6 and now they get to host a Lions team that has struggled on the road all season. Detroit has a Net Yards per Play of +0.6 when playing at home, but that drops down to -0.3 on the road.

Their offense averages a half yard per play less when playing away from Ford Field.

Then there's the Lions' defense, which is one of the worst in the NFL. The team allowed the Rams to gain 7.7 yards against them in the Wild Card Round and then allowed the Buccaneers to average 6.8 yards per play against them in the Divisional Round. Allowing your opponent to outgain you by that much is unsustainable, especially now that you have to face the best offense in the NFL.

The 49ers lead the NFL in yards per play, EPA per play, and success rate. They're going to feed on this Lions defense. In order to keep pace, Detroit's offense may need to score on every possession, and I don't think they can do that on the road.

With the line getting below the magic number of 7.0, I'll lay the points with San Francisco.

Odds refresh periodically and are subject to change.

You can check out all of Iain's bets here!

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