Buccaneers vs. 49ers best NFL prop bets for Week 11 (Target Brandon Aiyuk vs. Tampa Bay)

San Francisco 49ers wide receiver Brandon Aiyuk (11)
San Francisco 49ers wide receiver Brandon Aiyuk (11) / Cooper Neill/GettyImages

The San Francisco 49ers came out of its BYE week and got back to its winning ways, blowing out the Jacksonville Jaguars.

The Niners head home to face the Tampa Bay Buccaneers and are expected to win by double digits. If that's the case, what player props should we target on Sunday? I'm eyeing Brandon Aiyuk's receiving yards prop as well as Baker Mayfield passing yards prop.

Here's my two favorites come Sunday, but you can find a bet on EVERY Week 11 matchup with our betting expert Iain MacMillian's Road to 272!

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Best Prop Bets for Buccaneers vs. 49ers

  • Brandon Aiyuk OVER 67.5 Receiving Yards
  • Baker Mayfield UNDER 235.5 Passing Yards

Brandon Aiyuk OVER 67.5 Receiving Yards

Aiyuk has emerged as the most consistent threat in the Niners passing game, getting at least six targets in every game but last week against the Jaguars in a blowout. I think that's giving us a break on Aiyuk's receiving total on Sunday, which he has cleared in only four games.

So, Aiyuk isn't typically going over this number, but he has an advantageous matchup against a Buccaneers defense that is bottom 10 in EPA/Pass, which should set up San Francisco to have a big day through the air, and Aiyuk is the vertical passing weapon, averaging more than 17 yards per catch.

I'll go over on Sunday.

Baker Mayfield UNDER 235.5 Passing Yards

San Francisco upgraded its pass rush at the trade deadline, acquiring Chase Young from the Washington Commanders, and should only help the Niners, who are top five in EPA/Pass this season. The Buccaneers passing game has been limited all season, right around the league average in terms of passing success rate.

Sure, the Bucs are likely to be down for much of this game, but I'm not rushing to trust Mayfield to air it out on Sunday against this 49ers defense that can also play ball control. Mayfield is off two straight games against of 250 or more yards against the Titans and Texans, but this is the first time he'll face a top five EPA/Pass defense this season.

I think we see Tampa Bay really struggle against an elite defense.

Game odds refresh periodically and are subject to change.

Track Reed's bets here!