Best NFL prop bets for 49ers vs. Rams in NFL Week 2 (Back Brandon Aiyuk)

The San Francisco 49ers looked dominant in Week 1 and at least Brandon Aiyuk could have just as easy a time in Week 2 against LA.

San Francisco 49ers wide receiver Deebo Samuel (19)
San Francisco 49ers wide receiver Deebo Samuel (19) / Gregory Fisher-USA TODAY Sports

You could make a case that the San Francisco 49ers looked like the best team in the NFL in Week 1 with their win over the Pittsburgh Steelers.

They dominated Pittsburgh 30-7, but the Los Angeles Rams didn’t look bad either. Sean McVay’s team beat the Seahawks 30-13 in Seattle and unlike Pittsburgh, Seattle was a playoff team last season. 

The 49ers are favored on the road at SoFi Stadium as Kyle Shanahan and Sean McVay renew their rivalry in Week 2.

I have my three best prop bets for this matchup and we’re backing San Fran’s big defensive addition to make an NFC West statement in his first divisional matchup. 

Before we get into the picks, you should get into this promo from the DraftKings Sportsbook. Just sign up with the link below then bet $5 on any NFL game and receive $200 in bonus bets win or lose. 

Best NFL prop bets for 49ers vs. Rams

  • Brandon Aiyuk over 57.5 receiving yards 
  • Javon Hargrave over 0.5 sacks 
  • Matthew Stafford over 43.5 pass attempts

Brandon Aiyuk over 57.5 receiving yards 

Deebo Samuel is still the biggest name in the receiving group for the 49ers, but Aiyuk might be the No. 1 guy this season. He was a force of nature in Week 1 with eight catches for 129 yards and two touchdowns. This week against a rather inexperienced and ineffective group of corners he’ll dominate again. 

The Rams did not get strong performance from their cornerbacks even while holding Seattle to 13 points. Akhello Witherspoon and Derion Kendrick both received a 57.6 PFF grade which ranked 52nd out of 83 cornerbacks across the NFL.

Witherspoon had a coverage grade of 55.3 though the Seahawks only threw for 112 yards. That had more to do with the Seattle offense than the LA defense. 

Javon Hargrave over 0.5 sacks 

The Rams offensive line was severely depleted last season, so they’ve done their best to retool it. Steve Avila was their second round pick out of TCU and he held up well at left guard in Week 1, but San Francisco’s interior pass rush is much better than Seattle’s. 

Hargrave had three tackles and a sack in his San Francisco debut after posting a career high 11 sacks with the Eagles in 2022. Hargrave had three total pressures in Week 1 against an experienced and highly paid interior offensive line for the Steelers.

He’ll feast against Avila in his second NFL game. 

Matthew Stafford over 33.5 pass attempts

In Week 1 Stafford finally looked healthy again.

He looked like one of the best quarterbacks in the NFL, especially in a Week when so many of the top QBs struggled. He completed 24 of 38 passes for 334 yards with an average depth of target of 11.8 yards.

Sean McVay knows that his team’s greatest strength right now is its elite quarterback and while he’s healthy McVay is going to put the ball in Stafford’s hands a lot. 

The Rams were not efficient on the ground in that game at all. Kyren Williams carried the ball 15 times for 52 yards and two touchdowns, but that’s just 3.5 yards per carry.

Cam Akers was even worse with 29 yards on 22 carries and one TD. Akers was at 1.3 yards per carry.

The 49ers only allowed 41 rushing yards in Week 1. If the Rams are going to pull off an unlikely upset it’ll be because Stafford throws the ball 40 times and Sean McVay knows that. 

Game odds refresh periodically and are subject to change.

Follow all Josh Yourish’s bets HERE.