Bengals vs. 49ers prediction, odds, spread, injuries, trends for NFL Week 8

The San Francisco 49ers looked almost unbeatable early in the season, but now they've all of a sudden lost two straight games Can they get back on track in Week 8 when they welcome the Bengals off a BYE week?

Make no mistake about it, the 49ers are still one of the few elite teams in the NFL despite the two recent losses. I think they'll prove that this week and I'll break down why I think that later in this article.

It's worth noting that Brock Purdy may miss this game due to being on concussion protocol. If he does, Sam Darnold will get the start for the 49ers. As a result, the 49ers have moved from 5.5-point favorites to +3.5-point underdogs.

If you want my best bet for every game on the Week 8 slate, you can find them in the latest edition of the Road to 272 Bets here.

If you want to bet on this interconference showdown, you should do so at FanDuel Sportsbook. If you click the link below to sign up for an account, you'll be given $200 in bonus bets and receive 4 months of NBA League Pass when you place your first $5 bet!

Bengals vs. 49ers odds, spread, and total

Bengals vs. 49ers betting trends

• The UNDER is 6-2 in the Bengals' last eight games
• Bengals are 1-4 ATS in their last five games vs. 49ers
• The UNDER is 5-1 in the Bengals' last six road games
• 49ers are 13-5 ATS in their last 18 games
• 49ers are 10-0 ATS in their last 10 home games

Bengals vs. 49ers injury reports

Cincinnati Bengals injury report

• Akeem Davis-Gaither - LB - Questionable
• Devin Harper - LB - Questionable

San Francisco 49ers injury report

• Trent Williams - OT - Questionable
• Demetrius Flannigan-Fowles - LB - Questionable
• Deebo Samuel - WR - Out

Bengals vs. 49ers how to watch

• Date: Sunday, October 29
• Game Time: 4:25 p.m. EST
• Venue: Levi's Stadium
• How to Watch (TV): CBS
• Cincinnati Bengals Record: 3-3
• San Francisco 49ers Record: 5-2

Bengals vs. 49ers key players to watch

Cincinnati Bengals

Joe Burrow: There's no denying the Bengals haven't been themselves since the start of the NFL season, likely due to Joe Burrow's bum calf that has kept him from being at 100%. Now that the Bengals had a BYE week, it's time for Burrow to take a step forward and start to look like the Burrow of old.

San Francisco 49ers

Sam Darnold: If Brock Purdy does miss Sunday's game, as the reports indicate, Sam Darnold will be making his 49ers debut. He was a failed experiment in both New York and Carolina, but now that he's going to play on a team where he'll be surrounded by superstars, we'll see if he can hold his own.

Bengals vs. 49ers prediction and pick

I liked the 49ers at -5.5 with Brock Purdy and I still like them at -3.5 with Sam Darnold. This bet isn't about the 49ers as much as it's about the Bengals. I still have no faith in this Bengals team and I think the oddsmakers are still overvaluing them. They enter this week in 31st in the NFL in Net Yards per Play at -1.4 and still haven't looked impressive in their three wins.

Until the Bengals impress me, I will be betting against them.

The 49ers are still an elite team, coming in at fourth in Net Yards per Play at +1.1 and their success isn't solely due to Purdy so I'm fine with still betting on them with Darnold under center. Christian McCaffrey, Brandon Aiyuk, and their defense are good enough to beat this Bengals team as long as Darnold doesn't hand Cincinnati the win.

I'll take the 49ers to win and cover.

Odds refresh periodically and are subject to change.

You can check out all of Iain's bets here!