49ers schedule 2022: 5 games Niners fans won’t want to miss

The Miami Dolphins against the San Francisco 49ers (Photo by Thearon W. Henderson/Getty Images)
The Miami Dolphins against the San Francisco 49ers (Photo by Thearon W. Henderson/Getty Images) /
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San Francisco 49ers, Los Angeles Chargers
Los Angeles Chargers defensive end Anthony Lanier (90) tackles San Francisco 49ers wide receiver Shawn Poindexter Mandatory Credit: Stan Szeto-USA TODAY Sports /

No. 2 can’t-miss game on 49ers schedule 2022: Week 10 vs. Chargers

The Chargers are coming to town in 2022 with a revitalized roster and a reason to have to compete in every game this season after their whole division improved.

The Bosa brothers (Nick and Joey) will clash for the very first time in their young careers against one another in a California matchup that is must-see TV. The Chargers will enter the game with a much-improved defense, too, after acquiring some key pieces in the offseason.

Los Angeles added All-Pro EDGE Khalil Mack and interception leader over the past two seasons, cornerback J.C. Jackson. The Bolts also added veteran tight end Gerald Everett and re-signed stud receiver Mike Williams.

Primetime is the perfect spotlight for this game and has the potential to be one of the best games of the NFL regular season. Assuming health, the Chargers and 49ers have the most talented rosters on paper in the entire league. Quarterback Justin Herbert and the high-powered offense versus the Niners’ elite pass rush should make for a very entertaining ballgame between these two clubs.

Plus, it’ll sure be fun to see a Nick Bosa-versus-Joey Bosa matchup, even though they won’t physically go at each other on the field at the same time.