4 biggest challenges 49ers will face in Week 7 bout vs. Colts

No. 4: Jimmy Garoppolo will need time to reacclimate

Rookie quarterback Trey Lance (knee) has been ruled out, meaning Week 7 will again be all about Jimmy Garoppolo.

Garoppolo and the San Francisco offense have been notoriously inconsistent this season. And aside from the first half against the Detroit Lions in Week 1, and the opening drive versus the Seattle Seahawks in Week 4, Garoppolo’s efforts to start games haven’t exactly been great. If anything, he’s taken a while to proverbially “get going” in games.

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On top of that, the fact Garoppolo has been absent from the field for an extended period of time is a bit worrisome, too. Jimmy G exited at halftime during that Week 4 loss to Seattle, meaning he hasn’t played in three weeks. Sure, the Colts are dealing with a slew of injuries within their secondary, and their pass rush isn’t exactly anything to brag about, owning the league’s worst pressure percentage at 16.1 percent.

But when one mixes in the absence and shoddy weather, it’s not hard to see why Garoppolo could take a lot of time to get into any sort of groove.

And he’s had difficulty doing that under the best of conditions anyway.

Still, if the 49ers want to pull off the win against Indianapolis, they’ll need to make sure Garoppolo does his job.