49ers vs. Cardinals: 5 Niners who help Trey Lance out the most

Trent Sherfield #81 of the San Francisco 49ers with Trey Lance #5 (Photo by Gregory Shamus/Getty Images)
Trent Sherfield #81 of the San Francisco 49ers with Trey Lance #5 (Photo by Gregory Shamus/Getty Images) /
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Deebo Samuel, San Francisco 49ers
San Francisco 49ers wide receiver Deebo Samuel (19) Mandatory Credit: Raj Mehta-USA TODAY Sports /

No. 1: 49ers Wide Receiver Deebo Samuel

Pretty simple enough: The NFL’s leading pass-catcher helping out a rookie quarterback starting his first-ever pro game.

Wide receiver Deebo Samuel has already established something of a rapport with Trey Lance, hauling in two of the rookie’s touchdown passes in Week 4 as part of what’s turned into a 490-yard effort over the first four weeks.

Yet the overwhelming majority of Samuel’s yards this season, obviously, came at the hand of Jimmy Garoppolo. As such, it’ll be interesting to see whether or not Lance relies heavily on the third-year pro, too.

If so, realizing the Cardinals will be without their top cornerback this game, Byron Murphy who’s out with a ribs injury, might be the perfect opportunity for Lance to continue his budding rapport with Samuel. Sure, Arizona is likely to hone in on Samuel, especially if George Kittle is also out. But finding those matchups worth exploiting is going to be part of Lance’s maturation process.

One that’ll be equally as important as accuracy, arm strength or whatever other measurable.

Needless to say, if Lance and Samuel wind up continuing their growing relationship, this first-ever start for the rookie could be awfully promising.

Next. Ranking 49ers' 10 best players over first 4 weeks of 2021. dark