Bills vs. SF 49ers: 5 matchups that determine Week 13 outcome

Wide receiver T.J. Graham #11 of the Buffalo Bills (Photo by Brian Bahr/Getty Images)
Wide receiver T.J. Graham #11 of the Buffalo Bills (Photo by Brian Bahr/Getty Images) /
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Deebo Samuel, SF 49ers
San Francisco 49ers wide receiver Deebo Samuel (19) Mandatory Credit: Kyle Terada-USA TODAY Sports /

No. 2: SF 49ers’ Deebo Samuel vs. Bills’ Tre’Davious White

The SF 49ers also got wide receiver Deebo Samuel back in Week 12 from a lengthy hamstring injury, and he sure made the difference with 11 receptions for 133 yards.

One can only hope he has that kind of impact again.

This time, one of the primary defensive backs lining up opposite him will be Buffalo’s best, Tre’Davious White.

White has again been great for the Bills defense, registering 44 tackles while picking off two interceptions and managing another seven passes defended. All this has greatly influenced Buffalo owning a solid pass defense giving up 6.5 yards per play, which stands in the middle of the pack.

But it’s going to be the way the Niners use Samuel that could ultimately be beneficial.

Buffalo’s issues defending the run could open up more chances for Samuel to find chunk gains on jet sweeps and end-arounds — plays San Francisco used to great effect against a very good Rams run defense last week.

If Samuel has another signature-type game in Week 13, the SF 49ers could easily come out on top.

Provided the final matchup on this list goes the Niners’ way.