5 problems 49ers have to overcome in Week 10 vs. Seahawks

SANTA CLARA, CA - DECEMBER 16: George Kittle #85 of the San Francisco 49ers is tackled by Barkevious Mingo #51 of the Seattle Seahawks after a catch during their NFL game at Levi's Stadium on December 16, 2018 in Santa Clara, California. (Photo by Thearon W. Henderson/Getty Images)
SANTA CLARA, CA - DECEMBER 16: George Kittle #85 of the San Francisco 49ers is tackled by Barkevious Mingo #51 of the Seattle Seahawks after a catch during their NFL game at Levi's Stadium on December 16, 2018 in Santa Clara, California. (Photo by Thearon W. Henderson/Getty Images) /
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SANTA CLARA, CA – OCTOBER 22: Tyler Lockett #16 of the Seattle Seahawks makes a catch for a 43-yard touchdown against the San Francisco 49ers during their NFL game at Levi’s Stadium on October 22, 2015 in Santa Clara, California. (Photo by Thearon W. Henderson/Getty Images)
SANTA CLARA, CA – OCTOBER 22: Tyler Lockett #16 of the Seattle Seahawks makes a catch for a 43-yard touchdown against the San Francisco 49ers during their NFL game at Levi’s Stadium on October 22, 2015 in Santa Clara, California. (Photo by Thearon W. Henderson/Getty Images) /

No. 1: Defending Wide Receivers Tyler Lockett, D.K. Metcalf

It’s a pretty good bet Russell Wilson will do damage against the 49ers defense on Monday night.

Exactly how he goes about doing so, however, is anyone’s guess. But if someone wanted to bet on that, too, a good route to go would be with Seahawks wide receivers Tyler Lockett at the rookie, D.K. Metcalf.

San Francisco 49ers
San Francisco 49ers /

San Francisco 49ers

Lockett has been Wilson’s favorite target this season, already having accumulated 59 receptions for 767 yards and six touchdowns — all Seattle team highs.

Metcalf, meanwhile, has an impressive 29 receptions for 525 yards and five touchdowns.

Both Seahawks wideouts posted well over 100 receiving yards apiece with three combined touchdowns in Seattle’s Week 9 win over the Tampa Bay Buccaneers.

The Seahawks love to feature Lockett out of the slot, meaning nickel cornerback K’Waun Williams will have his hands full with this crucial matchup. On the outside, Metcalf will have to battle it out with boundary 49ers corners Richard Sherman and likely Emmanuel Moseley, who is still filling in for the injured third-year pro, Ahkello Witherspoon.

There are plenty of other factors and X-factors working for the Niners here, including whether or not their pass rush is getting home against Wilson.

Still, defending both Lockett and Metcalf will have massive ramifications on what is shaping up to be San Francisco’s most challenging game of the 2019 season to date.

Next. 5 matchups 49ers must win vs. Seahawks in Week 10. dark

The 49ers and Seahawks kick off on Monday, Nov. 11 at 8:15 p.m. from Levi’s Stadium.