No. 3: OT Justin Skule
Head coach Kyle Shanahan will certainly put Skule in a position to succeed by keeping guys like Kittle and running back Matt Breida in to help in pass protection.
Skule will line up in front of defensive end Bud Dupree for most of the game.
Dupree has an early season grade of 66.1 from Pro Football Focus. Dupree is far from an elite pass-rusher, though.
If Skule can neutralize him, he can significantly help minimize the loss of Staley.