No. 2: 2014 NFC Championship Game versus the Seattle Seahawks
This game hurts for a number of reasons.
First, it gave rise to the Seattle Seahawks as dominant players in the NFC West — a statement no 49ers fan wants to hear.
Second, All-Pro linebacker NaVorro Bowman suffered his gruesome knee injury, which kept him out of the entire subsequent 2014 season. And one could argue he never was the same caliber player afterwards.
Lastly, and most painfully, the Niners lost in painful fashion.
Trailing 23-17 in the waning minutes of the fourth quarter, Colin Kaepernick managed to engineer a drive to Seattle’s 18-yard line.
But with just 30 seconds left in regulation, Kap’s fade pass to Michael Crabtree (again with this play?) was tipped by Sherman and into the hands of linebacker Malcolm Smith.
Of course, we remember Sherman’s epic tirade, going off on Crabtree after the game:
Seattle got the last laugh. The Seahawks went on to easily defeat the Denver Broncos in Super Bowl XLVIII.
And, ironically, both Sherman and Smith would soon call San Francisco home.