4. Khalil Mack
There’s really nothing to say about Khalil Mack, other than he’s an absolute machine for the Oakland Raiders.
Impressive from his first game in the NFL, Mack has register double-digit sacks in his last three seasons in the NFL.
He’s not even the best AFC West player the 49ers have to face (more on that in a moment), but his ability to play all facets of the game equally well will give Niners head coach Kyle Shanahan headaches for days.
Mack is one of those rare defenders who can pull a MVP-worthy season off, and while good luck seeing a defender win an MVP award, Mack is entering the prime of his career and will be a significant thorn in the 49ers’ side come their battle in Week 9.