San Francisco 49ers: First-take regular-season schedule predictions for 2018

SANTA CLARA, CA - DECEMBER 24: Jimmy Garoppolo #10 of the San Francisco 49ers signalsto his team during their NFL game against the Jacksonville Jaguars at Levi's Stadium on December 24, 2017 in Santa Clara, California. (Photo by Robert Reiners/Getty Images)
SANTA CLARA, CA - DECEMBER 24: Jimmy Garoppolo #10 of the San Francisco 49ers signalsto his team during their NFL game against the Jacksonville Jaguars at Levi's Stadium on December 24, 2017 in Santa Clara, California. (Photo by Robert Reiners/Getty Images) /
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SAN FRANCISCO, CA – SEPTEMBER 16: Matthew Stafford #9 of the Detroit Lions lines up the offense against the San Francisco 49ers defense at Candlestick Park on September 16, 2012 in San Francisco, California. (Photo by Ezra Shaw/Getty Images)
SAN FRANCISCO, CA – SEPTEMBER 16: Matthew Stafford #9 of the Detroit Lions lines up the offense against the San Francisco 49ers defense at Candlestick Park on September 16, 2012 in San Francisco, California. (Photo by Ezra Shaw/Getty Images) /

Week 2 vs. Detroit Lions

After coming home from a tough, physical road loss to open up the season, the 49ers get to take out their frustrations against a fellow NFC North opponent, the Detroit Lions.

San Francisco’s home opener at Levi’s Stadium, kicking off at 4:25 p.m. ET on Sept. 16, should play right into the Niners’ hands. And, unfortunately, against all those fans sitting on the eastern concourse at Levi’s.

It’s hot. Good for San Francisco, but not so much for Detroit.

OK, the weather is a minimal factor. But chew on this — the Lions weren’t particularly active in free agency this offseason. And while their offense put up the seventh most points in the NFL a year ago (410), their rush offense ranked dead last in the league.

Barring some breakout NFL Draftee Lions running back, San Francisco’s defensive game plan will be to shut down Detroit quarterback Matthew Stafford.

A doable task.

Yet the more provocative storyline will be Jimmy Garoppolo taking on first-year head coach Matt Patricia, who served as the New England Patriots’ defensive coordinator prior to taking over duties in Detroit this year.

What will Patricia’s game plan be for Jimmy G? Or, what Niners fans would like to hear, how will Garoppolo go about carving up a defense he knows all too well?

Prediction: 49ers 27, Lions 18