Ken MacAfee (1978-1979)
The 49ers were hoping to land a bona fide playmaker when they selected Notre Dame tight end Ken MacAfee in Round 1 of the 1978 draft — No. 7 overall.
MacAfee netted just over 200 yards receiving his rookie season and backed it up with a slightly less impressive 266-yard, four-touchdown effort the subsequent year.
True, San Francisco was bad — very bad — during his tenure with the team. But it’s safe to say MacAfee was quickly becoming a bust.
The Niners coaching staff suggested he switch positions to offensive guard, but MacAfee declined. He later went on to pursue a career in dentistry, and his NFL career lasted just those two seasons.
All that for the seventh-overall pick in 1978.
Backup: Adrian Cooper (1996)
Tight end Adrian Cooper had some decent years with the Pittsburgh Steelers and Minnesota Vikings, but he turned into a complete bust when the 49ers brought him in for the 1996 season
He never played in the NFL again.
Next: Running Back