Defensive Ends: Todd Kelly (1993-1994), Israel Ifeanyi (1996)
Defensive Tackles: Reggie McGrew (1999-2002), Kentwan Balmer (2008-2009)
The 49ers drafted defensive end Todd Kelly with the 27th overall pick in the 1993 draft hoping to find a replacement for the pass-rushing specialist Charles Haley, who had left the team two years before.
In all, Kelly would start only six games with the 49ers over two years, recording 4.5 sacks.
Oh, and future New York Giants great Michael Strahan was still on the board when San Francisco took him at No. 27.
Equally as disappointing was defensive end Israel Ifeanyi. Ifeanyi wound up playing in only three games his rookie year before being released by San Francisco. That was the extent of his NFL career despite being a second-round pick in the 1996 NFL draft.
The 49ers have had some bad defensive tackles as well, and Reggie McGrew and Kentwan Balmer top the list for obvious reasons.
McGrew was the No. 24 overall pick of the 1999 draft but showed up to his first training camp out of shape. Injuries and continued setbacks kept him off the field, and he started zero of just 22 games played during his three-year Niner career.
Balmer was another first-round prospect the 49ers would hope would boost what was then an up-and-coming defense.
But Balmer did nothing of the sort and started just two games with San Francisco over his two-year stint.
Backups: Gabe Wilkins, Defensive End (1998-1999), Marques Douglas, Defensive Tackle/End (2005-2008)
Defensive end Gabe Wilkins was a prized free-agent acquisition, but injuries derailed his 49er career. He was out of the NFL after 1999.
Fellow defensive lineman Marques Douglas wasn’t exactly horrible, but he never mirrored the type of stats posted with the Baltimore Ravens prior to signing a lucrative contract with the 49ers in 2005.
Next: Offensive Line